BMAL1:CLOCK,NPAS2 activates circadian gene expression

Summation

As inferred from mouse, BMAL1:CLOCK (ARNTL:CLOCK) and BMAL1:NPAS2 (ARNTL:NPAS2) heterodimers bind to sequence elements (E boxes) in the promoters of target genes and enhance transcription (Gekakis et al. 1998, reviewed in Munoz and Baler 2003).

Participants

Events

• p-BMAL1:p-CLOCK,NPAS2 binds AVP gene (Homo sapiens)
• Expression of AVP (Homo sapiens)
• p-BMAL1:p-CLOCK,NPAS2 binds DBP gene (Homo sapiens)
• Expression of DBP (Homo sapiens)
• p-BMAL1:p-CLOCK,NPAS2 binds BHLHE40 gene (Homo sapiens)
• Expression of DEC1 (BHLHE40, BHLHB2) (Homo sapiens)
• p-BMAL1:p-CLOCK,NPAS2 binds BHLHE41 (DEC2) gene (Homo sapiens)
• Expression of DEC2 (BHLHE41, BHLHB3) (Homo sapiens)
• p-BMAL1:p-CLOCK,NPAS2 binds F7 gene (Homo sapiens)
• Expression of FACTOR VII (F7) (Homo sapiens)
• p-BMAL1:p-CLOCK,NPAS2 binds CCRN4L (NOCTURNIN) gene (Homo sapiens)
• Expression of CCRN4L (NOCTURNIN) (Homo sapiens)
• p-BMAL1:p-CLOCK,NPAS2 binds SERPINE1 gene (Homo sapiens)
• Expression of SERPINE1 (PAI-1) (Homo sapiens)
• p-BMAL1:p-CLOCK,NPAS2 binds PPARA gene (Homo sapiens)
• Expression of PPARA (Homo sapiens)
• p-BMAL1:p-CLOCK,NPAS2 binds NAMPT gene (Homo sapiens)
• Expression of NAMPT (NamPRT, PBEF, Visfatin) (Homo sapiens)
• p-BMAL1:p-CLOCK,NPAS2 binds KLF15 gene (Homo sapiens)
• Expression of KLF15 (Homo sapiens)

Participant Of

hasEvent

• Circadian Clock

Authored

May, B  (2011-06-22)

Reviewed

Albrecht, U  (2010-06-23)

D'Eustachio, P  (2009-05-27)

Delaunay, F  (2010-06-23)

Hirota, T  (2010-06-23)

Kay, SA  (2010-06-23)

Created

May, B  (2011-06-30)