BMAL1:CLOCK,NPAS2 activates circadian gene expression

Stable Identifier
R-HSA-1368108
Type
Pathway
Species
Homo sapiens
Compartment
extracellular region, nucleoplasm, endoplasmic reticulum lumen, cytosol
Locations in the PathwayBrowser
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Summation

As inferred from mouse, BMAL1:CLOCK (ARNTL:CLOCK) and BMAL1:NPAS2 (ARNTL:NPAS2) heterodimers bind to sequence elements (E boxes) in the promoters of target genes and enhance transcription (Gekakis et al. 1998, reviewed in Munoz and Baler 2003).

Literature References
PubMed ID Title Journal Year
9616112 Role of the CLOCK protein in the mammalian circadian mechanism

Gekakis, N, Staknis, D, Nguyen, HB, Davis, FC, Wilsbacher, LD, King, DP, Takahashi, JS, Weitz, CJ

Science 1998
12868535 The circadian E-box: when perfect is not good enough

Muņoz, E, Baler, R

Chronobiol Int 2003
Participants
Events
Participant Of
hasEvent
Authored
May, B  (2011-06-22)
Reviewed
Albrecht, U  (2010-06-23)
D'Eustachio, P  (2009-05-27)
Delaunay, F  (2010-06-23)
Hirota, T  (2010-06-23)
Kay, SA  (2010-06-23)