ABC transporters in lipid homeostasis

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R-HSA-1369062
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Pathway
Species
Homo sapiens
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A defined subset of the ABC transporter superfamily, the ABCA transporters, are highly expressed in monocytes and macrophages and are regulated by cholesterol flux which may indicate their role in in chronic inflammatory diseases (Schmitz and Kaminski 2001, Schmitz et al. 2000). Some D and G members of the ABC transporter family are also important in lipid transport (Voloshyna & Reiss 2011, Morita & Imanaka 2012, Morita et al. 2011).

Literature References
PubMed ID Title Journal Year
11048892 ABC transporters in cellular lipid trafficking

Schmitz, G, Kaminski, WE, Orsó, E

Curr Opin Lipidol 2000
21039332 ABC subfamily D proteins and very long chain fatty acid metabolism as novel targets in adrenoleukodystrophy

Morita, M, Shimozawa, N, Kashiwayama, Y, Suzuki, Y, Imanaka, T

Curr Drug Targets 2011
21352852 The ABC transporters in lipid flux and atherosclerosis

Voloshyna, I, Reiss, AB

Prog. Lipid Res. 2011
22366764 Peroxisomal ABC transporters: structure, function and role in disease

Morita, M, Imanaka, T

Biochim. Biophys. Acta 2012
11229879 ABC transporters and cholesterol metabolism

Schmitz, G, Kaminski, WE

Front Biosci 2001
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