SHP2 is phosphorylated

Stable Identifier
R-HSA-1369115
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Prolactin stimulation leads to tyrosine phosphorylation of the C-terminal SH2 domain of SHP2 and requires JAK2 (Ali et al. 1996). This has a positive regulatory influence on PRLR signaling. SHP2 has a number of signaling-capable interactors such as signal regulatory proteins (SIRPs, Kharitonenkov et al. 1997), SH2-containing inositol phosphatase (SHIP, Liu et al. 1997), insulin receptor substrates 1 and 2 (Myers et al. 1998), JAK2 (Jiao et al. 1996) and GRB2 associated binder 2 (GAB2) an adaptor protein that links activated receptor tyrosine kinase and cytokine receptors to downstream signaling molecules. PRL stimulation leads to SHP2-GAB2 association, GAB2 tyrosine phosphorylation, and GAB2-PI3K p85 subunit association, though it is not clear that this is the order of events, nor that SHP2 serves as a link between PRLR and GAB2 (Ali & Ali 2000).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
non-membrane spanning protein tyrosine kinase activity of PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:SHP2 [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created