PRLR is phosphorylated at Ser-349

Stable Identifier
R-HSA-1370505
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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The PRL responsiveness of target cells is negatively regulated by receptor internalization, ubiquitination and degradation, which limit the duration and intensity of receptor signaling (Djiane et al. 1981, 1982, Lu et al. 2002). The PRLR is phosphorylated on Ser-349 by an unidentified kinase (Li et al. 2006) enabling subsequent recruitment of the SCF beta-TrCP ubiquitin ligase complex (Li et al. 2004).

Literature References
PubMed ID Title Journal Year
15082796 Negative regulation of prolactin receptor stability and signaling mediated by SCF(beta-TrCP) E3 ubiquitin ligase

Li, Y, Kumar, KG, Tang, W, Spiegelman, VS, Fuchs, SY

Mol Cell Biol 2004
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