Reactome | BAK1 [mitochondrial outer membrane]

BAK1 [mitochondrial outer membrane]

Stable Identifier

R-HSA-139896

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Synonyms

Inactive BAK protein

Icon

Locations in the PathwayBrowser for interactor UniProt:P06463 VE6

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External Reference Information

External Reference

UniProt:Q16611 BAK1

Gene Names

BAK1, BAK, BCL2L7, CDN1

Chain

initiator methionine:, chain:2-211

Reference Genes

COSMIC (genes):BAK1 BAK1

ENSEMBL:ENSG00000030110 BAK1

HGNC:949 BAK1

UCSC:Q16611 BAK1

Other Identifiers

11732515_x_at

11746208_a_at

11748849_a_at

11752413_a_at

1687_s_at

17018274

203728_PM_at

203728_at

2950756

2950757

2950758

2950759

2950760

2950762

2950763

2950764

2950765

2950766

2950768

3398380

578

8125766

846_s_at

A_23_P145357

GE60444

GO:0001776

GO:0001782

GO:0001783

GO:0001836

GO:0001974

GO:0002262

GO:0002352

GO:0002376

GO:0003674

GO:0005215

GO:0005515

GO:0005739

GO:0005741

GO:0005783

GO:0005829

GO:0006915

GO:0006950

GO:0007005

GO:0008053

GO:0008285

GO:0008630

GO:0009410

GO:0009620

GO:0010046

GO:0010225

GO:0010248

GO:0010332

GO:0010524

GO:0010629

GO:0012501

GO:0014070

GO:0015288

GO:0016020

GO:0022414

GO:0031018

GO:0031072

GO:0031100

GO:0031334

GO:0031966

GO:0032469

GO:0032471

GO:0033137

GO:0034620

GO:0034644

GO:0035108

GO:0042542

GO:0042802

GO:0042803

GO:0042981

GO:0043065

GO:0043226

GO:0044325

GO:0044346

GO:0044877

GO:0045471

GO:0045862

GO:0046872

GO:0046902

GO:0046930

GO:0046982

GO:0048597

GO:0048856

GO:0048872

GO:0050673

GO:0051087

GO:0051400

GO:0051604

GO:0051649

GO:0051726

GO:0051881

GO:0055085

GO:0060068

GO:0060402

GO:0061024

GO:0070059

GO:0070242

GO:0071260

GO:0090200

GO:0090201

GO:0097136

GO:0097145

GO:0097190

GO:0097192

GO:0097193

GO:0097202

GO:1900103

GO:1901029

GO:1901030

GO:1902262

GO:1903896

GO:2001233

HMNXSV003007423

ILMN_1805990

PH_hs_0005134

TC06001588.hg

U16811_s_at

U16812_s_at

X84213_s_at

g4502362_3p_at

Participates

as an input of

tBID binds to inactive BAK protein (Homo sapiens)

as a component of

tBID bound to inactive BAK [mitochondrial outer membrane] (Homo sapiens)

Other forms of this molecule

BAK1 activated [mitochondrial outer membrane]

Inferred To

BAK1 [mitochondrial outer membrane] (Bos taurus)

BAK1 [mitochondrial outer membrane] (Canis familiaris)

Bak1 [mitochondrial outer membrane] (Rattus norvegicus)

BAK1 activated [mitochondrial outer membrane] (Gallus gallus)

BAK1 activated [mitochondrial outer membrane] (Mus musculus)

BAK1 activated [mitochondrial outer membrane] (Sus scrofa)

Cross References

ENSEMBL

ENSP00000363591, ENST00000442998, ENST00000374467, ENSP00000391258

OpenTargets

ENSG00000030110

HPA

ENSG00000030110-BAK1

PRO

Q16611

Pharos - Targets

Q16611

Interactors (30)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q07820 MCL1	1	MCL1 [cytosol] (R-HSA-5661490)	0.96	19
UniProt:Q07817 BCL2L1	2	BCL2L1 [cytosol] (R-HSA-50771) BCL2L1 [mitochondrial outer membrane] (R-HSA-114236)	0.958	38
UniProt:Q07817-1 BCL2L1			0.942	13
UniProt:Q16611 BAK1	2	BAK1 [mitochondrial outer membrane] (R-HSA-139896) BAK1 activated [mitochondrial outer membrane] (R-HSA-50690)	0.792	5
UniProt:P55957 BID	4	MYS-BID(62-195) [mitochondrial outer membrane] (R-HSA-114266) MYS-BID(62-195) [cytosol] (R-HSA-141373) BID(1-195) [cytosol] (R-HSA-50825) BID(62-195) [cytosol] (R-HSA-139953)	0.761	4
UniProt:Q07812 BAX	3	BAX [mitochondrial outer membrane] (R-HSA-139949) BAX activated [cytosol] (R-HSA-139907) BAX [cytosol] (R-HSA-139916)	0.758	6
UniProt:Q92843 B2CL2			0.718	8
UniProt:Q16548 BCL2A1	1	BCL2A1 [cytosol] (R-HSA-9725307)	0.718	6
UniProt:P06463 VE6			0.683	5
UniProt:P70444	4	Bid [mitochondrial outer membrane] (R-MMU-114266) Bid [cytosol] (R-MMU-141373) Bid [cytosol] (R-MMU-50825) Bid [cytosol] (R-MMU-139953)	0.676	3
UniProt:P24356 PG045			0.632	6
UniProt:P97287 MCL1			0.611	3
UniProt:P10415 BCL2	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.609	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:Q9Y3C5 RNF11			0.556	3
UniProt:Q9UBB4 ATX10			0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:Q8WXH2 JPH3			0.556	3
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:G5E9A7 G5E9A7			0.556	3
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.556	3
UniProt:Q86WV8 Q86WV8			0.556	3
UniProt:P00441 SOD1	5	2xHC-SOD1 [cytosol] (R-HSA-3299726) SOD1 [cytosol] (R-HSA-350697) 2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082) SOD1 [extracellular region] (R-HSA-350705)	0.556	3
UniProt:P49810 PSEN2	2	PSEN2(298-448) [plasma membrane] (R-HSA-9013329) PSEN2(1-297) [plasma membrane] (R-HSA-201599)	0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:Q05086 UBE3A	1	UBE3A [cytosol] (R-HSA-976028)	0.544	2
UniProt:P21796 VDAC1	7	p-S65-Ub:VDAC1 [mitochondrial outer membrane] (R-HSA-9834991) K63polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-9834037) K48polyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-5205624) Ub-VDAC1 [mitochondrial outer membrane] (R-HSA-9834989) VDAC1 [mitochondrial outer membrane] (R-HSA-1267988) VDAC1 [mitochondrial intermembrane space] (R-HSA-1267960) PolyUb-VDAC1 [mitochondrial outer membrane] (R-HSA-6783079)	0.544	2
UniProt:Q80U63	5	MFN2 [mitochondrial outer membrane] (R-MMU-992714) Ub-MFN2 [mitochondrial outer membrane] (R-MMU-9835010) K48polyUb-MFN2 [mitochondrial outer membrane] (R-MMU-5205668) K63polyUb-MFN2 [mitochondrial outer membrane] (R-MMU-9834043) p-S65-Ub:MFN2 [mitochondrial outer membrane] (R-MMU-9834980)	0.539	3
UniProt:O95140 MFN2	5	p-S65-Ub:MFN2 [mitochondrial outer membrane] (R-HSA-9834980) K63polyUb-MFN2 [mitochondrial outer membrane] (R-HSA-9834043) K48polyUb-MFN2 [mitochondrial outer membrane] (R-HSA-5205668) Ub-MFN2 [mitochondrial outer membrane] (R-HSA-9835010) MFN2 [mitochondrial outer membrane] (R-HSA-992714)	0.527	2
UniProt:Q8IWA4 MFN1	5	p-S65-Ub:MFN1 [mitochondrial outer membrane] (R-HSA-9835008) K63polyUb-MFN1 [mitochondrial outer membrane] (R-HSA-9834040) K48polyUb-MFN1 [mitochondrial outer membrane] (R-HSA-5205679) Ub-MFN1 [mitochondrial outer membrane] (R-HSA-9834985) MFN1 [mitochondrial outer membrane] (R-HSA-992745)	0.527	2

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