Caspase-8 activates BID by cleavage

Stable Identifier
R-HSA-139898
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The caspase 8 -mediated cleavage of cytosolic, inactive p22 BID at internal Asp sites yields a major p15 and minor p13 and p11 fragments. After myristoylation, tBID translocates to mitochondria as an integral membrane protein.

Literature References
PubMed ID Title Journal Year
12804595 Caspase 8-mediated cleavage of the pro-apoptotic BCL-2 family member BID in p53-dependent apoptosis

Fischer, B, Coelho, D, Dufour, P, Bergerat, JP, Denis, JM, Gueulette, J, Bischoff, P

Biochem Biophys Res Commun 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of active caspase-8 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Created