TP53 stimulates BBC3 (PUMA) expression

Stable Identifier
R-HSA-139913
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
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TP53 (p53) stimulates the transcription of BBC3 (PUMA) (p53 upregulated modulator of apoptosis) (Nakano and Vousden 2001). The transcription of BBC3 is also stimulated by p53 family members TP63 (p63) and TP73 (p73) (Bergamaschi et al. 2004, Patel et al. 2008). ASPP proteins PPP1R13B (ASPP1) and TP53BP2 (ASPP2) form a complex with p53 family members and enhance transcriptional activation of BBC3 (Bergamaschi et al. 2004, Patel et al. 2008, Wilson et al. 2013).

Literature References
PubMed ID Title Journal Year
18676979 Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax

Patel, S, George, R, Autore, F, Fraternali, F, Ladbury, JE, Nikolova, PV

Nucleic Acids Res. 2008
23365256 ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo

Wilson, AM, Morquette, B, Abdouh, M, Unsain, N, Barker, PA, Feinstein, E, Bernier, G, Di Polo, A

J. Neurosci. 2013
14729977 ASPP1 and ASPP2: common activators of p53 family members

Bergamaschi, D, Samuels, Y, Jin, B, Duraisingham, S, Crook, T, Lu, X

Mol. Cell. Biol. 2004
11572983 Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

Han, J, Flemington, C, Houghton, AB, Gu, Z, Zambetti, GP, Lutz, RJ, Zhu, L, Chittenden, T

Proc. Natl. Acad. Sci. U.S.A. 2001
11463392 PUMA, a novel proapoptotic gene, is induced by p53

Nakano, K, Vousden, KH

Mol Cell 2001
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