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BBC3 [mitochondrial outer membrane]
Stable Identifier
R-HSA-140222
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
Synonyms
PUMA protein
Locations in the PathwayBrowser for interactor UniProt:P10415
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Activation of BH3-only proteins (Homo sapiens)
Activation of PUMA and translocation to mitochondria (Homo sapiens)
Translocation of BBC3 (PUMA) protein to mitochondria (Homo sapiens)
BBC3 [mitochondrial outer membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BXH1 BBC3
Gene Names
BBC3, PUMA
Chain
chain:1-193
Reference Genes
BioGPS Gene:27113 BBC3
COSMIC (genes):BBC3 BBC3
CTD Gene:27113 BBC3
dbSNP Gene:27113 BBC3
ENSEMBL:ENSG00000105327 BBC3
ENSEMBL_homo_sapiens_GENE:ENSG00000105327.18 BBC3
KEGG Gene (Homo sapiens):27113 BBC3
Monarch:27113 BBC3
NCBI Gene:27113 BBC3
OMIM:605854 BBC3
UCSC:Q9BXH1 BBC3
Reference Transcript
RefSeq:NM_001127241.2 BBC3
RefSeq:NM_014417.4 BBC3
RefSeq:NM_001127240.2 BBC3
RefSeq:NM_001127242.2 BBC3
RefSeq:XM_006723141.3 BBC3
Other Identifiers
11727706_a_at
11727707_a_at
16873675
1700_at
211692_PM_s_at
211692_s_at
27113
3866436
3866437
3866438
3866440
3866444
3866445
3866447
3866448
3866449
8037872
A_23_P382775
A_23_P90189
A_24_P305312
GE59487
GO:0001836
GO:0001844
GO:0005515
GO:0005739
GO:0005741
GO:0005783
GO:0005829
GO:0006886
GO:0006915
GO:0006919
GO:0006974
GO:0007005
GO:0008340
GO:0012501
GO:0023052
GO:0031334
GO:0032464
GO:0032471
GO:0034976
GO:0042771
GO:0043065
GO:0043226
GO:0043525
GO:0044346
GO:0045926
GO:0051209
GO:0055065
GO:0055085
GO:0061024
GO:0065003
GO:0070059
GO:0070227
GO:0070230
GO:0070231
GO:0070234
GO:0070245
GO:0071456
GO:0071479
GO:0090200
GO:0097190
GO:0097193
GO:0097194
GO:1900740
GO:1902237
GO:1903896
GO:2000271
GO:2001056
GO:2001244
HMNXSV003041216
TC19001661.hg
U82987_at
g13591689_3p_s_at
Participates
as a member of
Bcl-XL interacting BH3-only proteins [mitochondrial outer membrane] (Homo sapiens)
Bcl-2 interacting BH-3 only proteins [mitochondrial outer membrane] (Homo sapiens)
as an output of
Translocation of BBC3 (PUMA) protein to mitochondria (Homo sapiens)
Other forms of this molecule
BBC3 [cytosol]
Cross References
RefSeq
NP_055232.1
,
XP_006723204.1
,
NP_001120713.1
,
NP_001120714.1
,
NP_001120712.1
OpenTargets
ENSG00000105327
GeneCards
Q9BXH1
Ensembl
ENSP00000341155
,
ENSG00000105327
,
ENSP00000395862
,
ENST00000439096
,
ENST00000341983
PRO
Q9BXH1
Pharos - Targets
Q9BXH1
PDB
6QG8
,
4HNJ
,
6TQP
,
7DVD
,
7P0S
,
4BPJ
,
6QFM
,
7P9W
,
5UUL
,
7QTX
,
4BPI
,
4BPK
,
2M04
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q07817-1 BCL2L1
0.855
9
UniProt:P10415 BCL2
1
BCL2 [mitochondrial outer membrane]
(R-HSA-50757)
0.815
6
UniProt:Q07820 MCL1
1
MCL1 [cytosol]
(R-HSA-5661490)
0.759
5
UniProt:Q92843 B2CL2
0.713
3
UniProt:P97287 MCL1
0.71
5
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