Reactome | Arachidonic acid is oxidised to PGG2 by PTGS1

Arachidonic acid is oxidised to PGG2 by PTGS1

Stable Identifier

R-HSA-140355

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen, endoplasmic reticulum membrane

Synonyms

Arachidonic acid oxidised to PGG2

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Arachidonic acid is oxidised to PGG2 by PTGS1

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Prostaglandin G/H synthase PTGS1 exhibits a dual catalytic activity, a cyclooxygenase and a peroxidase. The cyclooxygenase function catalyzes the initial conversion of arachidonic acid to an intermediate, prostaglandin G2 (PGG2) (Hamberg et al. 1974, Nugteren 1973).

Literature References

PubMed ID	Title	Journal	Year
4521806	Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation Hamberg, M, Svensson, J, Wakabayashi, T, Samuelsson, B	Proc Natl Acad Sci U S A	1974
4776443	Isolation and properties of intermediates in prostaglandin biosynthesis Nugteren, DH, Hazelhof, E	Biochim Biophys Acta	1973