factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides

Stable Identifier
R-HSA-140599
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activated thrombin cleaves the A chains of factor XIII tetramers in a reaction stimulated by the presence of fibrin multimers (Lewis et al. 1985). The amino terminal portions of the A chains are released as activation peptides, which have no known function. The resulting factor XIII tetramer remains catalytically inactive.

Literature References
PubMed ID Title Journal Year
2866798 Regulation of formation of factor XIIIa by its fibrin substrates

Lewis, SD, Janus, TJ, Lorand, L, Shafer, JA

Biochemistry 1985
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of activated thrombin (factor IIa) [extracellular region]
Physical Entity
Activity
This event is regulated
Orthologous Events
Authored
Created