10xCbxE-F2(44-622) [extracellular region]

Stable Identifier
R-HSA-140674
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
10xCbxE-F2, prothrombin (factor II)
Icon
10xCbxE-F2(44-622) [extracellular region] icon
10xCbxE-F2(44-622) [extracellular region] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
873923 Primary structure of human prethrombin 2 and alpha-thrombin

Butkowski, RJ, Downing, MR, Elion, J, Mann, KG

J Biol Chem 1977
2825773 Nucleotide sequence of the gene for human prothrombin

Degen, SJ, Davie, EW

Biochemistry 1987
266717 Amino acid sequence of human prothrombin fragments 1 and 2

Hewett-Emmett, D, Walz, DA, Seegers, WH

Proc Natl Acad Sci U S A 1977
External Reference Information
External Reference
UniProt:P00734 F2
Gene Names
F2
Chain
signal peptide:1-24, propeptide:25-43, chain:44-622, peptide:44-198, peptide:199-327, chain:328-363, chain:364-622
Reference Genes
BioGPS Gene:2147 F2
COSMIC (genes):F2 F2
CTD Gene:2147 F2
dbSNP Gene:2147 F2
ENSEMBL:ENSG00000180210.15 F2
HGNC:3535 F2
KEGG Gene (Homo sapiens):2147 F2
Monarch:2147 F2
NCBI Gene:2147 F2
OMIM:176930 F2
UCSC:P00734 F2
Reference Transcript
Other Identifiers
0005390725
11723003_a_at
11723004_x_at
11750896_a_at
16724411
205754_PM_at
205754_at
2147
3329476
3329477
3329479
3329480
3329481
3329482
3329483
3329484
3329485
3329487
3329488
3329489
3329490
3329491
3329492
3329493
3329494
3329499
3329501
3329502
3329503
37202_at
7939706
A_14_P137295
A_24_P85574
GE58225
GO:0001530
GO:0001934
GO:0002376
GO:0003674
GO:0004252
GO:0005102
GO:0005509
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005783
GO:0005788
GO:0005794
GO:0005796
GO:0005886
GO:0006508
GO:0006629
GO:0006953
GO:0006954
GO:0007166
GO:0007596
GO:0007599
GO:0008083
GO:0008150
GO:0008201
GO:0008233
GO:0008236
GO:0008284
GO:0008289
GO:0008360
GO:0009611
GO:0009897
GO:0010468
GO:0010544
GO:0014068
GO:0016787
GO:0023052
GO:0030154
GO:0030168
GO:0030193
GO:0030194
GO:0030307
GO:0030312
GO:0031012
GO:0032967
GO:0036211
GO:0042060
GO:0042730
GO:0043167
GO:0043226
GO:0045861
GO:0046427
GO:0048712
GO:0048856
GO:0051281
GO:0051480
GO:0051838
GO:0051918
GO:0055065
GO:0055085
GO:0061844
GO:0062023
GO:0070053
GO:0070062
GO:0070945
GO:0072562
GO:0090218
GO:0098542
GO:1900016
GO:1900182
GO:1900738
GO:2000379
HMNXSV003023107
ILMN_1671753
ILMN_3249291
M17262_at
PH_hs_0004418
TC11000401.hg
TC11002660.hg
g5922005_3p_at
Participates
as an input of
Other forms of this molecule
prothrombin (factor II) propeptide [Golgi lumen]
10xCbxE-F2(44-622) [Golgi lumen]
10xCbxE-F2(25-622) [Golgi lumen]
10xCbxE-F2(25-622) [endoplasmic reticulum lumen]
F2(25-622) [endoplasmic reticulum lumen]
thrombin heavy chain [plasma membrane]
thrombin light chain [plasma membrane]
10xCbxE-F2(44-327) [extracellular region]
thrombin heavy chain [extracellular region]
thrombin light chain [extracellular region]
Inferred To
F2 [extracellular region] (Bos taurus)
F2 [extracellular region] (Gallus gallus)
F2 [extracellular region] (Mus musculus)
F2 [extracellular region] (Rattus norvegicus)
F2 [extracellular region] (Sus scrofa)
10xCbxE-F2(44-622) [extracellular region] (Canis familiaris)
10xCbxE-F2(44-622) [extracellular region] (Danio rerio)
Modified Residues
Name
L-gamma-carboxyglutamic acid at 75
Coordinate
75
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 72
Coordinate
72
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 69
Coordinate
69
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 68
Coordinate
68
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 63
Coordinate
63
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 62
Coordinate
62
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 59
Coordinate
59
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 57
Coordinate
57
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 50
Coordinate
50
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 49
Coordinate
49
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
PDB
2C93, 3EQ0, 1HAI, 1NY2, 1E0F, 6BJR, 2ZDA, 1SL3, 2A45, 5EW1, 1CA8, 1A46, 1SB1, 2PKS, 3RLY, 1TBZ, 2CF8, 6EO8, 2ZHW, 2R2M, 3DA9, 6EO6, 1QHR, 1MH0, 1GHX, 2JH5, 2ANK, 1JMO, 2BVX, 1W7G, 1DM4, 1GJ4, 3HTC, 5Z5X, 1A61, 1GHY, 3LDX, 1NRQ, 5JZY, 1Z8I, 1TMU, 5TO3, 3VXF, 1AY6, 4RN6, 1FPH, 1LHF, 3BEI, 4E05, 1AWF, 1LHC, 1GHV, 3P70, 1BMN, 5EW2, 2FEQ, 1ZGI, 4DT7, 4BAK, 3LU9, 1C1V, 1GJ5, 1D9I, 1AHT, 2V3H, 1NRR, 3QTO, 4UFG, 2GDE, 2PW8, 2A0Q, 1ZGV, 1TMB, 1SR5, 1KTT, 1LHD, 1A4W, 2C90, 1EOL, 3RMN, 3U8T, 2C8Y, 1SGI, 3BIV, 1YPJ, 4BAO, 2HWL, 1THP, 1O0D, 5E8E, 1D3T, 3DHK, 3EGK, 1BHX, 2BVR, 1A3B, 2PGB, 1AD8, 4DY7, 4O03, 1P8V, 1BTH, 1G37, 3UWJ, 2UUJ, 4H6S, 2ZO3, 1TA2, 4E7R, 1NRN, 4DII, 1NU9, 5EDM, 1EB1, 6EO9, 2ZHF, 3RMM, 4AYY, 2BVS, 1SG8, 2ZHQ, 1C1W, 1Z71, 5JDU, 3S7H, 1JWT, 1D3D, 2ZFP, 2B5T, 2JH6, 1C5O, 2ZGX, 1AI8, 1K22, 1KTS, 1HXE, 2ZG0, 2ZF0, 1QJ6, 5MJT, 2JH0, 2C8Z, 1PPB, 3E6P, 1A5G, 3PMH, 2C8X, 1C4Y, 2ZC9, 1QBV, 1UVS, 1MUE, 4H6T, 1YPG, 3SI4, 4BAQ, 2AFQ, 1H8D, 5AF9, 1HXF, 4CH8, 3HKJ, 5MLS, 1TQ0, 1C4U, 3SHA, 3BIU, 1C1U, 1DWC, 1H8I, 4LZ1, 6EO7, 3RM2, 1DWE, 1HAP, 1O5G, 3QWC, 3DT0, 3F68, 3EE0, 4HTC, 1MU6, 2ZIQ, 3JZ2, 1THS, 3D49, 7KME, 1AFE, 3S7K, 1AIX, 1YPK, 1D6W, 1B7X, 1BA8, 4BAN, 4AX9, 3QDZ, 4HZH, 1G32, 1XM1, 1NT1, 3GIS, 3R3G, 8KME, 3C1K, 5NHU, 5JFD, 2ZFQ, 1BB0, 1DX5, 4DIH, 3P6Z, 3BF6, 5CMX, 4UD9, 3U8R, 2CF9, 2BXT, 3NXP, 3VXE, 1IHS, 1DIT, 2ZGB, 4RKO, 2ZFF, 1DWD, 4AYV, 1RD3, 3QTV, 1JOU, 5GDS, 3BEF, 3B9F, 3T5F, 2ZFR, 1C4V, 4YES, 5AFY, 1ABJ, 1OOK, 1TWX, 1O2G, 2THF, 1D3Q, 1VZQ, 1A2C, 3RLW, 1Z8J, 4HFP, 4NZQ, 2ZDV, 2HGT, 4CH2, 5MM6, 1LHE, 2A2X, 1NRP, 1HDT, 1TB6, 5L6N, 3HAT, 2FES, 4I7Y, 6C2W, 3SQH, 4UEH, 1HAG, 2BDY, 1THR, 3SHC, 1EOJ, 1IHT, 1DWB, 4BOH, 3RMO, 5GIM, 5EDK, 1TMT, 1T4U, 1HAO, 1NM6, 1OYT, 4LZ4, 1WBG, 1SHH, 1NO9, 6V5T, 2HPQ, 5AFZ, 2HNT, 3UTU, 4THN, 3B23, 2ZHE, 1BCU, 1HAH, 3QLP, 3U69, 2CN0, 1HUT, 3SI3, 4UDW, 2ZI2, 4LXB, 1C5N, 1T4V, 3U8O, 3RML, 1G30, 1WAY, 3PO1, 1XMN, 1NU7, 1DOJ, 3SV2, 4RKJ, 1HGT, 1NRO, 3U9A, 1ZRB, 1TQ7, 4UFE, 2GP9, 5A2M, 2BXU, 1ABI, 1HLT, 5Z5W, 3P17, 3DD2, 1YPL, 3QX5, 1K21, 1UMA, 1BMM, 1D3P, 4LOY, 3BV9, 1QJ7, 1TA6, 5DO4, 1YPE, 4E06, 1AWH, 1QUR, 1D4P, 4UE7, 1A3E, 4UFD, 4MLF, 4BAM, 1AE8, 1YPM, 3SQE, 1DE7, 3RM0, 3U98, 1RIW, 1GHW, 1SFQ, 1TOM, 2V3O, 1VR1, 4AZ2, 2UUK, 3QGN, 1QJ1, 5AHG, 4UFF, 3K65, 1MU8, 1HBT, 2HPP, 1FPC, 3JZ1, 1NZQ, 4BAH, 3C27, 3DUX, 3GIC, 1C5L, 1LHG, 2PGQ, 2C8W, 2H9T, 1NRS, 2UUF, 3TU7, 2OD3, 1B5G, 2ZNK, 2ANM
ZINC - Investigational
ZINC - Metabolites
GeneCards
HPA
Ensembl
Pharos - Targets
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (4)
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