prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)

Stable Identifier
R-HSA-140700
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Membrane-bound factor Xa catalyzes the activation of small amounts of thrombin. The amino terminal portion of prothrombin is released as an activation peptide, which can be cleaved further by activated thrombin. Neither the full-length activation peptide nor its cleavage products have known functions.

Factor Xa (aka Factor X heavy chain), a cleavage product of coagulation factor X (F10), is a vitamin K-dependent glycoprotein able to convert prothrombin to thrombin during the blood clotting process. Factor Xa is a target for direct oral anticoagulant (DOAC) drugs that are direct factor Xa inhibitors (the so-called 'xabans') and used in the treatment and prevention of thromboembolic disorders (Galanis et al. 2014).

Literature References
PubMed ID Title Journal Year
14982929 The factor V activation paradox

Orfeo, T, Brufatto, N, Nesheim, ME, Xu, H, Butenas, S, Mann, KG

J Biol Chem 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of factor Xa [plasma membrane]
Physical Entity
Activity
This event is regulated
Orthologous Events
Authored
Created