Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
10xCbxE-F2(44-327) [extracellular region]
Stable Identifier
R-HSA-140786
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
thrombin activation peptide
Icon
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
Common Pathway of Fibrin Clot Formation (Homo sapiens)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Homo sapiens)
10xCbxE-F2(44-327) [extracellular region] (Homo sapiens)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Homo sapiens)
10xCbxE-F2(44-327) [extracellular region] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
2825773
Nucleotide sequence of the gene for human prothrombin
Degen, SJ
,
Davie, EW
Biochemistry
1987
266717
Amino acid sequence of human prothrombin fragments 1 and 2
Hewett-Emmett, D
,
Walz, DA
,
Seegers, WH
Proc Natl Acad Sci U S A
1977
External Reference Information
External Reference
UniProt:P00734 F2
Gene Names
F2
Chain
signal peptide:1-24, propeptide:25-43, chain:44-622, peptide:44-198, peptide:199-327, chain:315-363, chain:364-622
Reference Genes
BioGPS Gene:2147 F2
COSMIC (genes):F2 F2
CTD Gene:2147 F2
dbSNP Gene:2147 F2
ENSEMBL:ENSG00000180210 F2
HGNC:3535 F2
KEGG:hsa:2147 F2
Monarch:2147 F2
NCBI Gene:2147 F2
OMIM:176930 F2
UCSC:P00734 F2
Reference Transcript
RefSeq:NM_001311257.1 F2
RefSeq:NM_000506.4 F2
Other Identifiers
11723003_a_at
11723004_x_at
11750896_a_at
16724411
205754_PM_at
205754_at
2147
3329476
3329477
3329478
3329479
3329480
3329481
3329482
3329483
3329484
3329485
3329486
3329487
3329488
3329489
3329490
3329491
3329492
3329493
3329494
3329499
3329501
3329502
3329503
37202_at
7939706
A_14_P137295
A_24_P85574
GE58225
GO:0001530
GO:0001934
GO:0002376
GO:0003824
GO:0004175
GO:0004252
GO:0005102
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0005788
GO:0005796
GO:0005886
GO:0006508
GO:0006953
GO:0006954
GO:0007166
GO:0007186
GO:0007596
GO:0008083
GO:0008201
GO:0008233
GO:0008236
GO:0008284
GO:0008289
GO:0008360
GO:0009611
GO:0009897
GO:0010468
GO:0010544
GO:0016787
GO:0030168
GO:0030193
GO:0030194
GO:0030195
GO:0030307
GO:0030312
GO:0031012
GO:0032024
GO:0032967
GO:0042730
GO:0043226
GO:0045861
GO:0046427
GO:0048018
GO:0048712
GO:0048771
GO:0051281
GO:0051480
GO:0051838
GO:0051897
GO:0051918
GO:0060089
GO:0061844
GO:0062023
GO:0070053
GO:0070062
GO:0070945
GO:0072562
GO:0090218
GO:0098542
GO:0098772
GO:0140096
GO:1900016
GO:1900182
GO:1900738
GO:1990806
GO:2000379
HMNXSV003023107
M17262_at
PH_hs_0004418
TC11000401.hg
TC11002660.hg
g5922005_3p_at
Participates
as an output of
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst) (Homo sapiens)
prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst) (Homo sapiens)
Other forms of this molecule
thrombin light chain [extracellular region]
thrombin heavy chain [extracellular region]
10xCbxE-F2(44-622) [extracellular region]
thrombin light chain [plasma membrane]
thrombin heavy chain [plasma membrane]
F2(25-622) [endoplasmic reticulum lumen]
10xCbxE-F2(25-622) [endoplasmic reticulum lumen]
10xCbxE-F2(25-622) [Golgi lumen]
10xCbxE-F2(44-622) [Golgi lumen]
prothrombin (factor II) propeptide [Golgi lumen]
Inferred To
10xCbxE-F2(44-327) [extracellular region]
(Gallus gallus)
F2 [extracellular region]
(Bos taurus)
F2 [extracellular region]
(Canis familiaris)
F2 [extracellular region]
(Mus musculus)
F2 [extracellular region]
(Rattus norvegicus)
F2 [extracellular region]
(Sus scrofa)
f2 [extracellular region]
(Xenopus tropicalis)
Modified Residues
Name
L-gamma-carboxyglutamic acid at 75
Coordinate
75
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 72
Coordinate
72
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 69
Coordinate
69
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 68
Coordinate
68
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 63
Coordinate
63
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 62
Coordinate
62
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 59
Coordinate
59
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 57
Coordinate
57
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 50
Coordinate
50
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Name
L-gamma-carboxyglutamic acid at 49
Coordinate
49
PsiMod Name
L-gamma-carboxyglutamic acid [MOD:00041]
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.
Cross References
RefSeq
NP_000497.1
,
NP_001298186.1
ZINC - World Drugs
THRB_HUMAN
Guide to Pharmacology - Targets
2362
OpenTargets
ENSG00000180210
ENSEMBL
ENSP00000308541
,
ENST00000311907
ZINC - FDA approved
THRB_HUMAN
ZINC - Substances
THRB_HUMAN
ZINC - Biogenic
THRB_HUMAN
ZINC target
P00734
PRO
P00734
GlyGen
P00734
PDB
5MM6
,
3U98
,
2C8Y
,
1ABI
,
5CMX
,
1Z8J
,
2ZC9
,
1UVS
,
5EDK
,
1LHC
,
1SFQ
,
4BOH
,
1DOJ
,
2PW8
,
1C5L
,
1H8D
,
1K21
,
1D4P
,
1SR5
,
3U8O
,
1A3B
,
3U69
,
1YPE
,
1JOU
,
1NU7
,
3HTC
,
1SHH
,
1DX5
,
2C8Z
,
1A46
,
1A3E
,
6C2W
,
5AF9
,
1TA2
,
3SI4
,
8KME
,
4BAH
,
3UTU
,
3U9A
,
1YPJ
,
2HWL
,
1LHD
,
1THS
,
2ZDA
,
1C5N
,
1O5G
,
5GIM
,
1K22
,
1YPG
,
3PMH
,
3TU7
,
4O03
,
5Z5W
,
6V5T
,
2CF8
,
3VXE
,
2C8W
,
2UUJ
,
1RD3
,
1Z8I
,
6EO8
,
1O2G
,
2ZIQ
,
7KME
,
2C93
,
4HTC
,
1GJ5
,
2ZI2
,
1QHR
,
2A2X
,
1PPB
,
1P8V
,
3SV2
,
1VR1
,
1HAH
,
2V3O
,
3SHA
,
4E05
,
4RN6
,
3BIU
,
1TBZ
,
4LOY
,
1KTT
,
4UE7
,
3EE0
,
2C8X
,
3RMM
,
2A0Q
,
1HBT
,
6EO9
,
1G37
,
1AY6
,
3K65
,
1E0F
,
1THR
,
5JFD
,
2ZHQ
,
5GDS
,
1TQ0
,
1HAI
,
1D3D
,
2V3H
,
4THN
,
2GP9
,
4MLF
,
4RKJ
,
1AI8
,
5AHG
,
1UMA
,
1BA8
,
2BXU
,
3LDX
,
1NY2
,
1NRO
,
1BMM
,
1D3P
,
1MU8
,
1G32
,
5AFZ
,
1YPM
,
2ZHE
,
4NZQ
,
1A5G
,
2PGB
,
3RMN
,
2BVS
,
2HNT
,
3RM0
,
1D6W
,
7TPP
,
3C1K
,
1QJ6
,
5A2M
,
1BMN
,
4UD9
,
1D3Q
,
2ZFR
,
1AWH
,
1HUT
,
4BAQ
,
3DA9
,
1A2C
,
3BEF
,
4LZ4
,
3P17
,
1TWX
,
2B5T
,
2ANM
,
3E6P
,
1DIT
,
1ZGV
,
1C4V
,
2JH0
,
1CA8
,
2ZFF
,
1D9I
,
3RML
,
2GDE
,
3DHK
,
4RKO
,
1EOL
,
1C1W
,
1YPK
,
1C5O
,
4LZ1
,
2H9T
,
5MLS
,
2AFQ
,
3SI3
,
1WBG
,
4UFD
,
2ZGB
,
5TO3
,
3B9F
,
3RM2
,
1AE8
,
3QTO
,
1ZGI
,
3GIC
,
1AHT
,
1B5G
,
2BXT
,
5JDU
,
1NRN
,
1SB1
,
3QDZ
,
3EQ0
,
1MU6
,
3QLP
,
1G30
,
1YPL
,
2ZHF
,
4DIH
,
3HKJ
,
1HLT
,
3BEI
,
3RMO
,
2BVR
,
2ANK
,
4HZH
,
3QX5
,
2CF9
,
1A61
,
1NZQ
,
1C4U
,
1HXE
,
2PGQ
,
6EO7
,
2THF
,
1T4V
,
1JWT
,
1TMT
,
1C1V
,
4BAM
,
3D49
,
2ZFQ
,
3QTV
,
1NM6
,
2CN0
,
1SG8
,
2ZNK
,
1AFE
,
1GHV
,
1HGT
,
6BJR
,
1WAY
,
3RLY
,
2FEQ
,
1IHT
,
1LHF
,
1HXF
,
2UUF
,
1SGI
,
3JZ2
,
3UWJ
,
2HPQ
,
1NRQ
,
2A45
,
1Z71
,
5EDM
,
1TMU
,
5JZY
,
3QWC
,
5EW2
,
3B23
,
1QBV
,
4CH2
,
3P6Z
,
4AZ2
,
2ZF0
,
2JH5
,
2FES
,
3RLW
,
3F68
,
1HAO
,
1T4U
,
1QJ7
,
1XM1
,
4E7R
,
3DT0
,
3EGK
,
1NRP
,
1HDT
,
1D3T
,
4BAO
,
5E8E
,
4DII
,
1EB1
,
1DWD
,
1FPC
,
1AIX
,
1BTH
,
1NO9
,
3DD2
,
4DT7
,
1MUE
,
1C4Y
,
1TB6
,
6EO6
,
1HAP
,
1MH0
,
2HPP
,
8UF7
,
5NHU
,
1SL3
,
1C1U
,
4BAN
,
3R3G
,
1TOM
,
5EW1
,
1DWE
,
1FPH
,
2HGT
,
3GIS
,
5MJT
,
3BF6
,
4CH8
,
4HFP
,
1IHS
,
1LHE
,
3T5F
,
1XMN
,
2ZG0
,
1BHX
,
3BV9
,
4YES
,
2OD3
,
2R2M
,
1DWC
,
1B7X
,
1GHY
,
1TA6
,
4H6S
,
4UFE
,
4AYV
,
1O0D
,
1ZRB
,
4I7Y
,
3S7K
,
1DM4
,
2UUK
,
1ABJ
,
3VXF
,
2ZGX
,
1TMB
,
3QGN
,
1RIW
,
1NRS
,
2C90
,
1GJ4
,
1BB0
,
1THP
,
3S7H
,
1JMO
,
3U8R
,
4LXB
,
1HAG
,
1A4W
,
3LU9
,
4E06
,
3SHC
,
1KTS
,
3BIV
,
1OYT
,
2ZDV
,
5AFY
,
4UDW
,
1AD8
,
8BWW
,
3DUX
,
5L6N
,
2BDY
,
4AYY
,
4BAK
,
1H8I
,
4UEH
,
1NU9
,
5DO4
,
1VZQ
,
2ZFP
,
1W7G
,
4AX9
,
1GHW
,
3HAT
,
4UFG
,
3SQH
,
4DY7
,
1AWF
,
1DE7
,
2JH6
,
1LHG
,
5Z5X
,
1QJ1
,
1NT1
,
1QUR
,
3P70
,
3NXP
,
3JZ1
,
2BVX
,
3SQE
,
1TQ7
,
1NRR
,
1EOJ
,
3C27
,
1DWB
,
4H6T
,
3U8T
,
2PKS
,
1GHX
,
1OOK
,
4UFF
,
3PO1
,
1BCU
,
2ZHW
,
2ZO3
ZINC - Investigational
THRB_HUMAN
ZINC - Metabolites
THRB_HUMAN
HPA
ENSG00000180210-F2
Pharos - Targets
P00734
Orphanet
F2
ZINC - Predictions - Purchasable
THRB_HUMAN
HMDB Protein
HMDBP13521
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q846V4 Q846V4
0.733
5
IntAct:EBI-941456 ANTI-THROMBIN
0.558
8
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.527
2
UniProt:Q07021 C1QBP
3
C1QBP [plasma membrane]
(R-HSA-158123)
C1QBP [mitochondrial matrix]
(R-HSA-9645697)
C1QBP [cytosol]
(R-HSA-9645690)
0.462
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text