factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain

Stable Identifier
R-HSA-140847
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Once the A chains of the Factor XIII tetramer have been cleaved by thrombin, the complex dissociates and the resulting A chain dimer binds Ca++ (one per peptide monomer) to form activated factor XIII (factor XIIIa).

Literature References
PubMed ID Title Journal Year
2866798 Regulation of formation of factor XIIIa by its fibrin substrates

Lewis, SD, Janus, TJ, Lorand, L, Shafer, JA

Biochemistry 1985
Participants
Participant Of
Orthologous Events
Authored
Created