Reactome | FGB(31-44) [extracellular region]

FGB(31-44) [extracellular region]

Stable Identifier

R-HSA-140876

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

fibrinopeptide B

Locations in the PathwayBrowser for interactor UniProt:Q96KB5 TOPK

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External Reference Information

External Reference

UniProt:P02675 FGB

Gene Names

FGB

Chain

signal peptide:1-30, peptide:31-44, chain:45-491

Reference Genes

BioGPS Gene:2244 FGB

COSMIC (genes):FGB FGB

CTD Gene:2244 FGB

dbSNP Gene:2244 FGB

ENSEMBL:ENSG00000171564 FGB

HGNC:3662 FGB

KEGG:hsa:2244 FGB

Monarch:2244 FGB

NCBI Gene:2244 FGB

OMIM:134830 FGB

UCSC:P02675 FGB

Reference Transcript

Other Identifiers

11715628_a_at

11746819_a_at

11755934_x_at

11758728_at

16971643

204988_PM_at

204988_at

216238_PM_s_at

216238_s_at

2244

2748550

2748552

2748553

2748554

2748555

2748556

2748557

2748558

2748559

2748560

2748561

2748562

2748563

2748564

2748565

2748566

2748567

2748568

2748569

2748570

37019_at

47589_at

63760_at

78341_at

8097910

A_14_P100691

A_23_P136125

GE62817

GO:0002250

GO:0002376

GO:0003013

GO:0005102

GO:0005198

GO:0005201

GO:0005515

GO:0005576

GO:0005577

GO:0005615

GO:0005783

GO:0005886

GO:0005938

GO:0007155

GO:0007160

GO:0007596

GO:0009897

GO:0009986

GO:0030168

GO:0030312

GO:0031012

GO:0031091

GO:0031093

GO:0031410

GO:0031639

GO:0034116

GO:0042730

GO:0043152

GO:0043226

GO:0044320

GO:0045087

GO:0045202

GO:0045907

GO:0045921

GO:0050714

GO:0050839

GO:0051087

GO:0051258

GO:0051592

GO:0051604

GO:0062023

GO:0065003

GO:0070062

GO:0070374

GO:0070527

GO:0071347

GO:0072378

GO:0072562

GO:0090277

GO:0098542

GO:1900026

GO:1902042

GO:1903561

GO:2000352

HMNXSV003033495

Hs.7645.1.S1_3p_a_at

Hs.7645.1.S1_3p_x_at

ILMN_1678049

ILMN_2114972

J00129_at

PH_hs_0023603

TC04000777.hg

g11761630_3p_at

Participates

as an output of

fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B (Homo sapiens)

as a member of

FGA, FGB, FGG [extracellular region] (Homo sapiens)

Other forms of this molecule

FGB [extracellular region]

FGB [plasma membrane]

FGB(31-491) [extracellular region]

FGB(31-491) [platelet alpha granule lumen]

Inferred To

FGB(31-44) [extracellular region] (Gallus gallus)

FGB [extracellular region] (Bos taurus)

FGB [extracellular region] (Canis familiaris)

FGB [extracellular region] (Sus scrofa)

Fgb [extracellular region] (Mus musculus)

Fgb [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_001171670.1, NP_005132.2

OpenTargets

ENSG00000171564

ENSEMBL

ENSP00000306099, ENST00000302068

HPA

ENSG00000171564-FGB

PRO

P02675

Pharos - Targets

P02675

GlyGen

P02675

Orphanet

FGB

HMDB Protein

HMDBP13514

PDB

6BIJ, 2XNX, 1LTJ, 2XNY, 3GHG, 6BIL, 2Z4E, 1FZG, 1FZF, 1FZE, 1LT9, 3BVH, 3E1I, 1N8E, 1RE4, 3HUS, 2HPC, 6V18, 1RE3, 3H32, 2Q9I, 6V13, 2OYI, 1RF1, 1RF0, 2OYH, 2HOD, 6V0Y, 2FFD, 2A45, 6V19, 6V15, 6V1A, 2H43, 1N86, 6ATZ, 1FZA, 1FZB, 1FZC, 2HLO

Interactors (53)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02671 FGA	8	FGA(20-866) [platelet alpha granule lumen] (R-HSA-140920) Variant fibrinogen alpha chain [extracellular region] (R-HSA-976905) FGA(20-866) [extracellular region] (R-HSA-140841) FGA [plasma membrane] (R-HSA-140916) p-FGA [endoplasmic reticulum lumen] (R-HSA-8957043) FGA [endoplasmic reticulum lumen] (R-HSA-8956714) FGA(20-35) [extracellular region] (R-HSA-140867) FGA [extracellular region] (R-HSA-140583)	0.852	11
UniProt:P27958-PRO_0000037566			0.543	4
UniProt:Q9GZZ1 NAA50			0.527	2
UniProt:Q9Y490 TLN1	4	TLN1 [extracellular region] (R-HSA-350693) TLN1(434-2541) [cytosol] (R-HSA-9855156) TLN1(1-433) [cytosol] (R-HSA-9855031) TLN1 [cytosol] (R-HSA-350713)	0.527	2
UniProt:Q9H993 ARMT1			0.527	2
UniProt:Q05639 EEF1A2	1	EEF1A2 [cytosol] (R-HSA-3907261)	0.527	2
UniProt:Q9NQG5 RPRD1B	1	RPRD1B [nucleoplasm] (R-HSA-6814894)	0.527	2
UniProt:Q9UNH7 SNX6			0.527	2
UniProt:Q00341 HDLBP	1	HDLBP [plasma membrane] (R-HSA-8858026)	0.527	2
UniProt:O43776 NARS1	1	NARS [cytosol] (R-HSA-379625)	0.527	2
UniProt:O95747 OXSR1			0.527	2
UniProt:Q08752 PPID	1	PPID [nucleoplasm] (R-HSA-8939168)	0.527	2
UniProt:Q9C0B1 FTO	1	FTO [nucleoplasm] (R-HSA-8857715)	0.527	2
UniProt:Q9NPD8 UBE2T	3	UBE2T [nucleoplasm] (R-HSA-420942) MonoUb-K91,K182-UBE2T [nucleoplasm] (R-HSA-6785362) Ub-C86-UBE2T [nucleoplasm] (R-HSA-8864217)	0.527	2
UniProt:P41743 PRKCI	3	PRKCI [nucleoplasm] (R-HSA-9021345) PRKCI [cytosol] (R-HSA-58206) PRKCI [plasma membrane] (R-HSA-420005)	0.527	2
UniProt:P62495 ETF1	3	ETF1 [cytosol] (R-HSA-54433) 4OHK63-ETF1 [cytosol] (R-HSA-9629948) Me-Q185-ETF1 [cytosol] (R-HSA-6800157)	0.527	2
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524)	0.527	2
UniProt:O60361 NME2P1	1	NME2P1 [cytosol] (R-HSA-6806876)	0.527	2
UniProt:Q9Y2L1 DIS3	2	DIS3 [nucleoplasm] (R-HSA-6791517) DIS3 [cytosol] (R-HSA-429935)	0.527	2
UniProt:Q92917 GPKOW	1	GPKOW [nucleoplasm] (R-HSA-8850839)	0.527	2
UniProt:Q8WZA0 LZIC			0.527	2
UniProt:P27348 YWHAQ	1	YWHAQ [cytosol] (R-HSA-1445116)	0.527	2
UniProt:Q9BY44 EIF2A			0.527	2
UniProt:O00625 PIR	1	PIR [nucleoplasm] (R-HSA-8953390)	0.527	2
UniProt:Q8WVY7 UBCP1			0.527	2
UniProt:Q99986 VRK1	2	VRK1 [cytosol] (R-HSA-2995381) VRK1 [nucleoplasm] (R-HSA-2528998)	0.527	2
UniProt:P61586 RHOA	6	RHOA [plasma membrane] (R-HSA-194510) RHOA [cell junction] (R-HSA-2134503) RHOA [cytosol] (R-HSA-194866) RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971) RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082)	0.527	2
UniProt:O60493 SNX3	3	SNX3 [cytosol] (R-HSA-3247743) PolyUb-SNX3 [endosome membrane] (R-HSA-6782993) SNX3 [endosome membrane] (R-HSA-6782991)	0.527	2
UniProt:Q15459 SF3A1	1	SF3A1 [nucleoplasm] (R-HSA-71962)	0.527	2
UniProt:P06899 H2BC11	9	HIST1H2BJ [nucleoplasm] (R-HSA-181900) Ub-121-HIST1H2BJ [nucleoplasm] (R-HSA-3364017) AcK13-HIST1H2BJ [nucleoplasm] (R-HSA-4568662) AcK16-HIST1H2BJ [nucleoplasm] (R-HSA-4568704) AcK6-HIST1H2BJ [nucleoplasm] (R-HSA-4568668) AcK21-HIST1H2BJ [nucleoplasm] (R-HSA-4568671) HIST1H2BJ [extracellular region] (R-HSA-977565) AcK-HIST1H2BJ [nucleoplasm] (R-HSA-4549258) Ub-HIST1H2BJ [nucleoplasm] (R-HSA-6782566)	0.527	2
UniProt:Q96FW1 OTUB1	2	OTUB1 [nucleoplasm] (R-HSA-6783242) OTUB1 [cytosol] (R-HSA-933411)	0.527	2
UniProt:Q96A49 SYAP1			0.527	2
UniProt:Q01581 HMGCS1	1	HMGCS1 [cytosol] (R-HSA-191329)	0.527	2
UniProt:Q9BY32 ITPA	1	ITPA [cytosol] (R-HSA-2509850)	0.527	2
UniProt:Q07960 ARHGAP1	1	ARHGAP1 [cytosol] (R-HSA-195193)	0.527	2
UniProt:P05091 ALDH2	1	ALDH2 [mitochondrial matrix] (R-HSA-71718)	0.527	2
UniProt:P36915 GNL1			0.527	2
UniProt:O95202 LETM1	2	LETM1 [endoplasmic reticulum membrane] (R-HSA-9714759) LETM1 [mitochondrial inner membrane] (R-HSA-8949702)	0.527	2
UniProt:P39748 FEN1	1	FEN1 [nucleoplasm] (R-HSA-54745)	0.527	2
UniProt:O75436 VPS26A	1	VPS26A [cytosol] (R-HSA-3247739)	0.527	2
UniProt:Q58FG1 HS904			0.527	2
UniProt:Q9Y3A5 SBDS			0.527	2
UniProt:Q9BXJ9 NAA15			0.527	2
UniProt:Q9NVS9 PNPO	1	PNPO [cytosol] (R-HSA-965023)	0.527	2
UniProt:Q9UL46 PSME2	2	PSME2 [nucleoplasm] (R-HSA-174350) PSME2 [cytosol] (R-HSA-68814)	0.527	2
UniProt:O43583 DENR			0.527	2
UniProt:Q16659 MAPK6 gene	6	p-3S,T MAPK6 [nucleoplasm] (R-HSA-5692665) MAPK6 [nucleoplasm] (R-HSA-5692686) p-S189 MAPK6 [nucleoplasm] (R-HSA-5687015) p-S189 MAPK6 [cytosol] (R-HSA-5687019) MAPK6 [cytosol] (R-HSA-5686979) ub-MAPK6 [cytosol] (R-HSA-5687000)	0.527	2
UniProt:Q15126 PMVK	1	PMVK [cytosol] (R-HSA-191348)	0.527	2
UniProt:Q9NTZ6 RBM12			0.527	2
UniProt:O75822 EIF3J	1	EIF3J [cytosol] (R-HSA-72534)	0.527	2
UniProt:P30043 BLVRB	1	BLVRB [cytosol] (R-HSA-189388)	0.527	2
UniProt:O43252 PAPSS1	3	PAPSS1 [cytosol] (R-HSA-174387) PAPSS1(1-223)-BRAF(381-766) fusion [cytosol] (R-HSA-6802432) PAPSS1(1-223)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802543)	0.527	2
UniProt:Q96KB5 TOPK			0.527	2

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