Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C

Stable Identifier
R-HSA-141040
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
protein C -> activated protein C + protein C heavy chain activation peptide
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Thrombin complexed with thrombomodulin at the endothelial cell surface cleaves the heavy chain of protein C, generating activated protein C and an activation peptide. The activation peptide has no known function.

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of activated thrombin:thrombomodulin [plasma membrane]
Physical Entity
Activity
This event is regulated
Orthologous Events
Authored
Reviewed
Created