Trimerization of TRAIL:TRAIL receptor complex

Stable Identifier
R-HSA-141139
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Trimerization of TNFSF10:TNFRSF10A,TNFRSF10B, Trimerization of TNFSF10:DR4,DR5
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The complex of TRAIL (TNFSF10) and TRAIL receptor-1 (TNFRSF10A) or TRAIL receptor-2 (TNFRSF10B) trimerizes (Sprick et al. 2000, Reis et al. 2011).

Literature References
PubMed ID Title Journal Year
20852190 Unraveling the binding mechanism of trivalent tumor necrosis factor ligands and their receptors

Reis, CR, van Assen, AH, Quax, WJ, Cool, RH

Mol. Cell Proteomics 2011
10894160 FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

Sprick, MR, Weigand, MA, Rieser, E, Rauch, CT, Juo, P, Blenis, J, Krammer, PH, Walczak, H

Immunity 2000
Participants
Participant Of
hasEvent
Orthologous Events
Reviewed
Created