TRAIL-mediated dimerization of procaspase-8

Stable Identifier
R-HSA-141156
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Monomeric caspase-8 zymogens undergo dimerization and subsequent conformational changes at the TRAIL:TRAIL receptor-2:FADD receptor complex leading to the formation of the catalytically active form of procaspase-8.

Literature References
PubMed ID Title Journal Year
12620239 A unified model for apical caspase activation

Boatright, KM, Renatus, M, Scott, FL, Sperandio, S, Shin, H, Pedersen, IM, Ricci, JE, Edris, WA, Sutherlin, DP, Green, DR, Salvesen, GS

Mol Cell 2003
10894160 FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

Sprick, MR, Weigand, MA, Rieser, E, Rauch, CT, Juo, P, Blenis, J, Krammer, PH, Walczak, H

Immunity 2000
Participants
Participant Of
This event is regulated
Negatively by
Orthologous Events
Reviewed
Created