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Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB
Stable Identifier
R-HSA-141333
Type
Pathway
Species
Homo sapiens
Compartment
mitochondrial outer membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Amine Oxidase reactions (Homo sapiens)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Homo sapiens)
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Human monoamine oxidases (MAOs) are flavin-containing enzymes that are present on the outer mitochondrial membrane and act on primary, secondary and tertiary amines. In contrast to the P450s which have a large number of isozymes, MAOs number only two isozymes, MAO-A and MAO-B. These gene products share over 70% sequence identity, are approximately 59KDa in size and have overlapping substrates (for example dopamine, tryamine and tryptamine) but each form also has distinct substrate specificities. MAO-A (primary type in fibroblasts) preferentially oxidises serotonin (5-Hydroxytryptamine) whereas MAO-B (primary type in platelets) prefers phenylethylamine. MAOs are of particular clinical interest because of the use of MAO inhibitors (MAOI) as antidepressants or in the treatment of neurodegenerative diseases Benedetti 2001, Beedham 1997).
Literature References
PubMed ID
Title
Journal
Year
11468017
Biotransformation of xenobiotics by amine oxidases
Benedetti, MS
Fundam Clin Pharmacol
2001
9443166
The role of non-P450 enzymes in drug oxidation
Beedham, C
Pharm World Sci
1997
Participants
Events
MAOB:FAD oxidatively deaminates TYR
(Homo sapiens)
MAOA:FAD oxidatively deaminates of 5HT
(Homo sapiens)
MAOB:FAD oxidatively deaminates of PEA
(Homo sapiens)
MAOA inhibitors bind MAOA:FAD
(Homo sapiens)
MAOB inhibitors bind MAOB:FAD
(Homo sapiens)
Participates
as an event of
Amine Oxidase reactions (Homo sapiens)
Event Information
Go Biological Process
xenobiotic metabolic process (0006805)
Orthologous Events
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Bos taurus)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Canis familiaris)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Danio rerio)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Dictyostelium discoideum)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Gallus gallus)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Mus musculus)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Rattus norvegicus)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Sus scrofa)
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000602
,
BIOMD0000000575
Authored
Jassal, B (2008-05-19)
Reviewed
D'Eustachio, P (2008-05-28)
Created
Jassal, B (2004-09-16)
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