PAOX:FAD oxidises NASPN to SPM

Stable Identifier
R-HSA-141351
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Acetylated spermine (NASPN) is oxidised by the flavoenzyme polyamine oxidase (PAOX, woth FAD as cofactor) to produce spermidine (SPM). PAOX is involved in the back-conversion of polyamines and thus the regulation of their intracellular concentrations (Vujcic et al. 2003).

Literature References
PubMed ID Title Journal Year
12477380 Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion

Vujcic, S, Liang, P, Diegelman, P, Kramer, DL, Porter, CW

Biochem J 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity of PAOX:FAD [peroxisomal matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created