Myristoylation of tBID by NMT1

Stable Identifier
R-HSA-141367
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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After proteolytic activation, tBID is myristoylated by NMT-1 at an exposed glycine. N-myristoylation may enable the activated tBID to associate with the lipid components of the mitochondrial membrane.

Literature References
PubMed ID Title Journal Year
11099414 Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis

Zha, J, Weiler, S, Oh, KJ, Wei, MC, Korsmeyer, SJ

Science 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
myristoyltransferase activity of NMT 1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Created