Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components

Stable Identifier
R-HSA-141405
Type
Pathway
Species
Homo sapiens
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The target of the mitotic checkpoint is the Anaphase Promoting Complex/Cyclosome (APC/C) an E3 ubiquitin ligase that targets proteins whose destruction is essential for mitotic exit. Currently, there are two proposed mechanism by which inhibition of the APC/C is achieved. These mechanisms differ depending on the mechanism of signal transduction. The APC/C may be inhibited directly by association with the Mitotic Checkpoint Complex (MCC) or through the sequestration of its activator, Cdc20.

Literature References
PubMed ID Title Journal Year
14593737 The mitotic checkpoint: a signaling pathway that allows a single unattached kinetochore to inhibit mitotic exit

Chan, GK, Yen, TJ

Prog Cell Cycle Res 2003
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Orthologous Events
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