Amplification of signal from the kinetochores

Stable Identifier
R-HSA-141424
Type
Pathway
Species
Homo sapiens
Compartment
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A single unattached kinetochore is capable of preventing cells from exiting mitosis. The mitotic checkpoint provides a way for a localized defect to affect the global biochemical status of the cell. In principle, the signal that is generated at an unattached kinetochore diffuses throughout the cell to affect its target. There are currently two models for how this is achieved. One model is based on the observation that the Mad2 checkpoint protein binds and is rapidly released from unattached kinetochores. The kinetochore is believed to act as a catalyst that converts Mad2 into an inhibitory state that diffuses throughout the cell upon its release from the kinetochore. A second model proposes that the signal is amplified by a kinase cascade much like a conventional signal transduction pathway. This kinase cascade is believed to be comprised of the checkpoint kinases, hBUBR1, hBUB1, hMPS1.

Literature References
PubMed ID Title Journal Year
14593737 The mitotic checkpoint: a signaling pathway that allows a single unattached kinetochore to inhibit mitotic exit

Chan, GK, Yen, TJ

Prog Cell Cycle Res 2003
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