Reactome | MAD1L1 [cytosol]

MAD1L1 [cytosol]

Stable Identifier

R-HSA-141433

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

HsMad1

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Locations in the PathwayBrowser for interactor UniProt:Q03718 NSE5

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - Mitotic Spindle Checkpoint (Homo sapiens)
    - Amplification of signal from the kinetochores (Homo sapiens)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
        
        Mad1 binds kinetochore (Homo sapiens)
        
        MAD1L1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y6D9 MAD1L1

Gene Names

MAD1L1, MAD1, TXBP181

Chain

chain:1-718

Reference Genes

BioGPS Gene:8379 MAD1L1

COSMIC (genes):MAD1L1 MAD1L1

CTD Gene:8379 MAD1L1

dbSNP Gene:8379 MAD1L1

ENSEMBL:ENSG00000002822 MAD1L1

ENSEMBL_homo_sapiens_GENE:ENSG00000002822.16 MAD1L1

HGNC:6762 MAD1L1

KEGG Gene (Homo sapiens):8379 MAD1L1

Monarch:8379 MAD1L1

NCBI Gene:8379 MAD1L1

OMIM:602686 MAD1L1

UCSC:Q9Y6D9 MAD1L1

Reference Transcript

Other Identifiers

11724206_a_at

11724207_x_at

11737802_a_at

17054479

17122978

17123104

17123106

204857_PM_at

204857_at

3035474

3035475

3035476

3035477

3035478

3035501

3035521

3035530

3035535

3035542

3035549

3035569

3035597

3035606

3035607

3035608

3035609

3035610

3035611

3035613

3035616

3035617

3035619

3035620

3035621

3035622

3939333

499_at

8137805

8379

A_23_P333735

A_33_P3569068

GE81301

GE85301

GO:0000278

GO:0000775

GO:0000776

GO:0000922

GO:0002376

GO:0005515

GO:0005634

GO:0005635

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0007049

GO:0007059

GO:0007094

GO:0007155

GO:0023052

GO:0042130

GO:0042802

GO:0043226

GO:0043229

GO:0043515

GO:0044615

GO:0048538

GO:0048856

GO:0051220

GO:0051301

GO:0051315

GO:0072686

GO:0090235

GO:0090267

GO:0097431

GO:0140014

GO:1901990

GO:1902426

GO:1990706

GO:1990728

HMNXSV003010542

ILMN_2358069

ILMN_2358074

PH_hs_0000759

U33822_at

g4505064_3p_s_at

Participates

as a component of

as an input of

Mad1 binds kinetochore (Homo sapiens)

Inferred To

Mad1l1 [cytosol] (Mus musculus)

Mad1l1 [cytosol] (Rattus norvegicus)

mad1 [cytosol] (Dictyostelium discoideum)

mad1 [cytosol] (Schizosaccharomyces pombe)

MAD1 [cytosol] (Saccharomyces cerevisiae)

mad1l1 [cytosol] (Danio rerio)

mad1l1 [cytosol] (Xenopus tropicalis)

Mad1 [cytosol] (Drosophila melanogaster)

MAD1L1 [cytosol] (Bos taurus)

MAD1L1 [cytosol] (Canis familiaris)

MAD1L1 [cytosol] (Gallus gallus)

MAD1L1 [cytosol] (Sus scrofa)

mdf-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001013858.1, NP_001291453.1, NP_001013859.1, NP_001291452.1, NP_003541.2, XP_005249934.1

OpenTargets

ENSG00000002822

GeneCards

Q9Y6D9

HPA

ENSG00000002822-MAD1L1

Ensembl

ENSP00000385334, ENSP00000384155, ENSG00000002822, ENST00000399654, ENST00000402746, ENSP00000265854, ENSP00000382562, ENST00000406869, ENST00000265854

PRO

Q9Y6D9

Pharos - Targets

Q9Y6D9

PDB

7B1H, 4DZO, 7B1F, 7B1J, 1GO4

Interactors (67)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13257 MAD2L1	2	MAD2L1 [cytosol] (R-HSA-141400) Activated MAD2L1 [cytosol] (R-HSA-141447)	0.982	50
UniProt:P06753 TPM3	3	TPM3 [cytosol] (R-HSA-390543) TPM3(2-258)insV-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9710837) TPM3(2-258)insV-ALK(1059-1620) fusion [cytosol] (R-HSA-9710848)	0.849	10
UniProt:Q9UL15 BAG5	1	BAG5 [cytosol] (R-HSA-5255453)	0.832	9
UniProt:P09917 ALOX5	6	p-S272-ALOX5 [cytosol] (R-HSA-265276) ALOX5 [secretory granule lumen] (R-HSA-6801306) ALOX5 [extracellular region] (R-HSA-6806468) ALOX5 [ficolin-1-rich granule lumen] (R-HSA-6801302) ALOX5 [cytosol] (R-HSA-429010) p-S272-ALOX5 [nuclear envelope] (R-HSA-2318765)	0.805	9
UniProt:Q9Y6D9 MAD1L1	1	MAD1L1 [cytosol] (R-HSA-141433)	0.804	11
UniProt:P09493 TPM1	1	TPM1 [cytosol] (R-HSA-390547)	0.782	7
UniProt:O76064 RNF8	1	RNF8 [nucleoplasm] (R-HSA-5682539)	0.781	7
UniProt:O76041 NEBL			0.781	7
UniProt:Q14134 TRIM29	1	TRIM29 [cytosol] (R-HSA-5624343)	0.781	7
UniProt:Q8TD31-3 CCHCR1			0.718	6
UniProt:Q3ZCW2 LEGL			0.718	6
UniProt:P09493-10 TPM1			0.718	6
UniProt:Q2TBE0 CWF19L2	1	CWF19L2 [nucleoplasm] (R-HSA-9770846)	0.718	6
UniProt:P55081 MFAP1	1	MFAP1 [nucleoplasm] (R-HSA-2396419)	0.718	6
UniProt:Q02224 CENPE	1	CENPE [cytosol] (R-HSA-376245)	0.591	3
UniProt:Q15013 MD2BP			0.577	4
UniProt:Q9DCX1 MD2BP			0.564	2
UniProt:Q9Z1B5	1	Mad2l1 [cytosol] (R-MMU-141400)	0.564	2
UniProt:P32571	1	DOA4 [cytosol] (R-SCE-6781794)	0.556	3
UniProt:Q9Y4E8 USP25	1	USP15 [cytosol] (R-HSA-2173138)	0.556	3
UniProt:Q9BSW7 SYT17			0.556	3
UniProt:Q96CS2 HAUS1	1	HAUS1 [cytosol] (R-HSA-8855199)	0.556	3
UniProt:Q86YD7 F90A1			0.556	3
UniProt:Q4G0R1 Q4G0R1			0.556	3
UniProt:P39976 DLD3			0.556	3
UniProt:Q63HK5 TSH3			0.556	3
UniProt:P32502	1	GCD7 [cytosol] (R-SCE-72519)	0.556	3
UniProt:Q5T7P8-2 SYT6			0.556	3
UniProt:P25786 PSMA1	2	PSMA1 [nucleoplasm] (R-HSA-174333) PSMA1 [cytosol] (R-HSA-68724)	0.556	3
UniProt:Q9Y4E8-2 USP15			0.556	3
UniProt:Q96BZ8 LENG1	1	LENG1 [nucleoplasm] (R-HSA-9769590)	0.556	3
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:P0DTD1-PRO_0000449631 REP			0.556	3
UniProt:Q03718 NSE5			0.556	3
UniProt:O43247-2 CIMIP4			0.556	3
UniProt:Q6NYC8 PPR18			0.556	3
UniProt:Q99576 TSC22D3	1	TSC22D3 [cytosol] (R-HSA-2682363)	0.556	3
UniProt:Q2TAC2-2 CCDC57			0.556	3
UniProt:Q9NX65 ZSCAN32	1	ZSCAN32 [nucleoplasm] (R-HSA-1247547)	0.556	3
UniProt:Q07002 CDK18			0.556	3
UniProt:Q99576-3 TSC22D3			0.556	3
UniProt:P28004 PRP45			0.556	3
UniProt:Q9Y6W3 CAPN7	1	CAPN7 [cytosol] (R-HSA-8848633)	0.556	3
UniProt:Q8TAP4-4 LMO3			0.556	3
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.556	3
UniProt:Q8TC71 MIEAP			0.556	3
UniProt:Q5VU62 Q5VU62			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:P53933 APP1			0.556	3
UniProt:Q9Y4C2-2 TCAF1			0.556	3
UniProt:Q9BZW7 TSG10			0.556	3
UniProt:Q92917 GPKOW	1	GPKOW [nucleoplasm] (R-HSA-8850839)	0.556	3
UniProt:P25800 LMO1	1	LMO1 [nucleoplasm] (R-HSA-8956514)	0.556	3
UniProt:Q9H1Y0 ATG5	3	ATG5 [phagocytic vesicle membrane] (R-HSA-5205636) GlyK130-ATG5 [cytosol] (R-HSA-5683582) ATG5 [cytosol] (R-HSA-936010)	0.556	3
UniProt:Q9BW85 YJU2	1	YJU2 [nucleoplasm] (R-HSA-9770430)	0.556	3
UniProt:Q9UM82 SPATA2	1	SPATA2 [cytosol] (R-HSA-9796351)	0.556	3
UniProt:Q9HAQ2 KIF9	1	KIF9 [cytosol] (R-HSA-984616)	0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:P13497 BMP1	1	BMP1 [extracellular region] (R-HSA-2002393)	0.527	2
UniProt:Q9Y240 CLC11			0.527	3
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.527	2
UniProt:Q8N4Q0 PTGR3			0.527	2
UniProt:O43448 KCNAB3	1	KCNAB3 [plasma membrane] (R-HSA-1297367)	0.527	2
UniProt:Q6NZI2 PTRF	2	PTRF [nucleoplasm] (R-HSA-74981) CAVIN1 [plasma membrane] (R-HSA-9714278)	0.527	2
UniProt:P12270 TPR	5	TPR M489P [nucleoplasm] (R-HSA-5661477) TPR L458P [nucleoplasm] (R-HSA-5661460) TPR(2-629)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711958) TPR(2-629)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711979) TPR [nucleoplasm] (R-HSA-157692)	0.524	2
UniProt:P03410 TAX			0.488	2
UniProt:O00267 SUPT5H	1	p-SUPT5H [nucleoplasm] (R-HSA-3009372)	0.488	2

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