Reactome | MAD1L1 [cytosol]

MAD1L1 [cytosol]

Stable Identifier

R-HSA-141433

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

HsMad1

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Locations in the PathwayBrowser for interactor UniProt:Q9BZW7 TSG10

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - Mitotic Spindle Checkpoint (Homo sapiens)
    - Amplification of signal from the kinetochores (Homo sapiens)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
        
        Mad1 binds kinetochore (Homo sapiens)
        
        MAD1L1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y6D9 MAD1L1

Gene Names

MAD1L1, MAD1, TXBP181

Chain

chain:1-718

Reference Genes

BioGPS Gene:8379 MAD1L1

COSMIC (genes):MAD1L1 MAD1L1

CTD Gene:8379 MAD1L1

dbSNP Gene:8379 MAD1L1

ENSEMBL:ENSG00000002822 MAD1L1

HGNC:6762 MAD1L1

KEGG Gene (Homo sapiens):8379 MAD1L1

Monarch:8379 MAD1L1

NCBI Gene:8379 MAD1L1

OMIM:602686 MAD1L1

UCSC:Q9Y6D9 MAD1L1

Reference Transcript

Other Identifiers

0000510373

11724206_a_at

11724207_x_at

11737802_a_at

15338

17054479

17122978

17123104

17123106

204857_at

3035474

3035475

3035476

3035477

3035478

3035501

3035521

3035530

3035535

3035542

3035549

3035569

3035597

3035606

3035607

3035608

3035609

3035610

3035611

3035613

3035616

3035617

3035619

3035620

3035621

3035622

3635

3939333

499_at

4DZO

8137805

8379

A_23_P333735

A_33_P3569068

AAC52059

AAD20359

AAD24498

AAH09964

AAP21876

AAS07503

AC005282

AC006433

AC069288

AC104129

AC110781

AF083811

AF123318

AK090959

BAG52253

BC009964

C9J9H5

C9JIR0

C9JJ38

C9JKI7

C9JX80

CAB015338

CCDS43539

CCDS78201

ENSG00000002822

ENSP00000265854

ENSP00000382562

ENSP00000384155

ENSP00000385334

ENST00000265854

ENST00000265854.11

ENST00000399654

ENST00000399654.6

ENST00000402746

ENST00000402746.5

ENST00000406869

ENST00000406869.5

EntrezGene:8379

EntrezGene:MAD1L1

g4505064_3p_s_at

GE81301

GE85301

GO:0000278

GO:0000775

GO:0000776

GO:0000777

GO:0000922

GO:0002376

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005635

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0007049

GO:0007059

GO:0007093

GO:0007094

GO:0007155

GO:0008150

GO:0008283

GO:0032991

GO:0042130

GO:0042802

GO:0043226

GO:0043515

GO:0044615

GO:0048538

GO:0048856

GO:0051276

GO:0051301

GO:0051315

GO:0072686

GO:0090235

GO:0097431

GO:0140014

GO:1901990

HGNC:6762

HPA003635

ILMN_1807902

ILMN_2358069

ILMN_2358074

IPR008672

MAD1L1

MAD1L1-201

MAD1L1-202

MAD1L1-203

MAD1L1-204

MIM:176807

MIM:602686

NM_001013836

NM_001013837

NM_001304523

NM_001304524

NM_003550

NP_001013858

NP_001013859

NP_001291452

NP_001291453

NP_003541

PF05557

PH_hs_0000759

U33822

U33822_at

UPI0000072C4D

UPI00003E282E

Participant Of

hasComponent

input

Mad1 binds kinetochore

Inferred To

MAD1L1 [cytosol] (Bos taurus)

MAD1L1 [cytosol] (Caenorhabditis elegans)

MAD1L1 [cytosol] (Canis familiaris)

MAD1L1 [cytosol] (Danio rerio)

MAD1L1 [cytosol] (Dictyostelium discoideum)

MAD1L1 [cytosol] (Drosophila melanogaster)

MAD1L1 [cytosol] (Gallus gallus)

MAD1L1 [cytosol] (Mus musculus)

MAD1L1 [cytosol] (Rattus norvegicus)

MAD1L1 [cytosol] (Saccharomyces cerevisiae)

MAD1L1 [cytosol] (Schizosaccharomyces pombe)

MAD1L1 [cytosol] (Sus scrofa)

MAD1L1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001291452.1, NP_001013858.1, NP_003541.2, NP_001013859.1, NP_001291453.1

OpenTargets

ENSG00000002822

GeneCards

Q9Y6D9

PRO

Q9Y6D9

PDB

1GO4, 4DZO

Interactors (59)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13257 MAD2L1	2	Activated MAD2L1 [cytosol] (R-HSA-141447) MAD2L1 [cytosol] (R-HSA-141400)	0.978	37
UniProt:P06753 TPM3	1	TPM3 [cytosol] (R-HSA-390543)	0.841	9
UniProt:Q9Y6D9 MAD1L1	1	MAD1L1 [cytosol] (R-HSA-141433)	0.804	11
UniProt:P09917 ALOX5	6	ALOX5 [cytosol] (R-HSA-429010) p-S272-ALOX5 [nuclear envelope] (R-HSA-2318765) ALOX5 [ficolin-1-rich granule lumen] (R-HSA-6801302) ALOX5 [extracellular region] (R-HSA-6806468) ALOX5 [secretory granule lumen] (R-HSA-6801306) p-S272-ALOX5 [cytosol] (R-HSA-265276)	0.795	8
UniProt:Q9UL15 BAG5	1	BAG5 [cytosol] (R-HSA-5255453)	0.766	6
UniProt:Q14134 TRIM29	1	TRIM29 [cytosol] (R-HSA-5624343)	0.764	6
UniProt:O76041 NEBL			0.764	6
UniProt:O76064 RNF8	1	RNF8 [nucleoplasm] (R-HSA-5682539)	0.764	6
UniProt:P09493 TPM1	1	TPM1 [cytosol] (R-HSA-390547)	0.718	6
UniProt:Q2TBE0 C19L2			0.696	5
UniProt:Q8TD31-3 CCHCR1			0.696	5
UniProt:P09493-10 TPM1			0.696	5
UniProt:P55081 MFAP1	1	MFAP1 [extracellular region] (R-HSA-2396419)	0.696	5
UniProt:Q3ZCW2 LEGL			0.696	5
UniProt:Q02224 CENPE	1	CENPE [cytosol] (R-HSA-376245)	0.591	3
UniProt:Q9DCX1 MD2BP			0.564	2
UniProt:Q9Z1B5	1	MAD2L1 [cytosol] (R-MMU-141400)	0.564	2
UniProt:P32571	4	USP43 [nucleoplasm] (R-SCE-5653784) USP19 [cytosol] (R-SCE-6781794) phospho-p-T945-USP8 [cytosol] (R-SCE-1358714) USP8 [cytosol] (R-SCE-917720)	0.556	3
UniProt:Q9Y4E8 USP15	1	USP15 [cytosol] (R-HSA-2173138)	0.556	3
UniProt:Q96CS2 HAUS1	1	HAUS1 [cytosol] (R-HSA-8855199)	0.556	3
UniProt:P39976 DLD3			0.556	3
UniProt:Q63HK5 TSH3			0.556	3
UniProt:P32502	1	EIF2B2 [cytosol] (R-SCE-72519)	0.556	3
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.556	3
UniProt:Q03718 NSE5			0.556	3
UniProt:Q9UM82 SPAT2			0.556	3
UniProt:Q9NX65 ZSCAN32	1	ZSCAN32 [nucleoplasm] (R-HSA-1247547)	0.556	3
UniProt:Q9BW85 YJU2			0.556	3
UniProt:Q99576-3 TSC22D3			0.556	3
UniProt:P28004 PRP45			0.556	3
UniProt:Q5VU62 Q5VU62			0.556	3
UniProt:P53933 APP1			0.556	3
UniProt:P12270 TPR	3	TPR L458P [nucleoplasm] (R-HSA-5661460) TPR M489P [nucleoplasm] (R-HSA-5661477) TPR [nucleoplasm] (R-HSA-157692)	0.524	2
UniProt:Q9BSW7 SYT17			0.488	2
UniProt:Q86YD7 F90A1			0.488	2
UniProt:Q4G0R1 Q4G0R1			0.488	2
UniProt:Q5T7P8-2 SYT6			0.488	2
UniProt:Q9Y4E8-2 USP15			0.488	2
UniProt:P03410 TAX			0.488	2
UniProt:Q96BZ8 LENG1			0.488	2
UniProt:Q96HA8 NTAQ1			0.488	2
UniProt:O43247-2 TEX33			0.488	2
UniProt:Q6NYC8 PPR18			0.488	2
UniProt:Q99576 TSC22D3	1	TSC22D3 [cytosol] (R-HSA-2682363)	0.488	2
UniProt:Q2TAC2-2 CCDC57			0.488	2
UniProt:Q07002 CDK18			0.488	2
UniProt:Q9Y6W3 CAPN7	1	CAPN7 [cytosol] (R-HSA-8848633)	0.488	2
UniProt:Q8TAP4-4 LMO3			0.488	2
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.488	2
UniProt:Q8TC71 MIEAP			0.488	2
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.488	2
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.488	2
UniProt:Q9BZW7 TSG10			0.488	2
UniProt:Q9Y4C2-2 TCAF1			0.488	2
UniProt:P25800 LMO1	1	LMO1 [nucleoplasm] (R-HSA-8956514)	0.488	2
UniProt:Q9HAQ2 KIF9	1	KIF9 [cytosol] (R-HSA-984616)	0.488	2
UniProt:O00267 SUPT5H	1	p-SUPT5H [nucleoplasm] (R-HSA-3009372)	0.488	2
UniProt:Q9H1Y0 ATG5	3	GlyK130-ATG5 [cytosol] (R-HSA-5683582) ATG5 [phagocytic vesicle membrane] (R-HSA-5205636) ATG5 [cytosol] (R-HSA-936010)	0.488	2
UniProt:Q92917 GPKOW	1	GPKOW [nucleoplasm] (R-HSA-8850839)	0.488	2