Reactome | BUB1B [cytosol]

BUB1B [cytosol]

Stable Identifier

R-HSA-141436

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

hBUBR1

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Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - Mitotic Spindle Checkpoint (Homo sapiens)
    - Amplification of signal from the kinetochores (Homo sapiens)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
        
        MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Mitotic checkpoint complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Mitotic checkpoint complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Mitotic checkpoint complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Mitotic checkpoint complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        Mad1 binds kinetochore (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Mitotic checkpoint complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Mitotic checkpoint complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        Release of activated MAD2 from kinetochores (Homo sapiens)
        
        Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Mitotic checkpoint complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Mitotic checkpoint complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
    - Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
      - Inactivation of APC/C via direct inhibition of the APC/C complex (Homo sapiens)
        
        Binding of the MCC complex to the APC/C complex (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        Formation of the MCC complex (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Separation of Sister Chromatids (Homo sapiens)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Mitotic checkpoint complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Mitotic checkpoint complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        Separation of sister chromatids (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Mitotic checkpoint complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Mitotic checkpoint complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - EML4 and NUDC in mitotic spindle formation (Homo sapiens)
        
        EML4 recruits NUDC to mitotic spindle (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Mitotic checkpoint complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Mitotic checkpoint complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
      - Kinetochore capture of astral microtubules (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Mitotic checkpoint complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Mitotic checkpoint complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
      - Resolution of Sister Chromatid Cohesion (Homo sapiens)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Mitotic checkpoint complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Mitotic checkpoint complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Mitotic checkpoint complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        Kinetochore assembly (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Mitotic checkpoint complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Mitotic checkpoint complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Mitotic checkpoint complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Mitotic checkpoint complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Mitotic checkpoint complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Mitotic checkpoint complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        Mitotic checkpoint complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
  - Regulation of mitotic cell cycle (Homo sapiens)
    - APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
      - Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC/C:Cdc20 mediated degradation of mitotic proteins (Homo sapiens)
        
        APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint (Homo sapiens)
        
        APC-Cdc20 mediated degradation of Nek2A (Homo sapiens)
        
        Association of Nek2A with MCC:APC/C (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        Degradation of multiubiquitinated Nek2A (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        Multiubiquitinated Nek2A [cytosol] (Homo sapiens)
        
        Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        Multiubiquitination of Nek2A (Homo sapiens)
        
        Multiubiquitinated Nek2A [cytosol] (Homo sapiens)
        
        Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        Nek2A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        Cdc20:Phospho-APC/C mediated degradation of Cyclin A (Homo sapiens)
        
        Association of Cyclin A with the APC/C (Homo sapiens)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        Degradation multiubiquitinated Cyclin A (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Homo sapiens)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        Ubiquitination of Cyclin A by APC/C:Cdc20 complex (Homo sapiens)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        multiubiquitinated Cyclin A associated with MCC:APC/C complex [cytosol] (Homo sapiens)
        
        Cdc2:Cyclin A:MCC:APC/C complex [cytosol] (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        Activation of APC/C:Cdc20 by dissociation of Cdc20:phospho-APC/C from Cdc20:phospho-APC/C:Mad2:Bub3:BubR1 (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        hBUBR1:hBUB3:MAD2* complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
      - Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
        
        Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
        
        Inactivation of APC/C via direct inhibition of the APC/C complex (Homo sapiens)
        
        Binding of the MCC complex to the APC/C complex (Homo sapiens)
        
        MCC:APC/C complex [cytosol] (Homo sapiens)
        
        hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        Formation of the MCC complex (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)
        
        hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
        
        BUB1B [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60566 BUB1B

Gene Names

BUB1B, BUBR1, MAD3L, SSK1

Chain

chain:1-1050

Reference Genes

BioGPS Gene:701 BUB1B

COSMIC (genes):BUB1B BUB1B

CTD Gene:701 BUB1B

dbSNP Gene:701 BUB1B

ENSEMBL:ENSG00000156970 BUB1B

HGNC:1149 BUB1B

KEGG Gene (Homo sapiens):701 BUB1B

Monarch:701 BUB1B

NCBI Gene:701 BUB1B

OMIM:602860 BUB1B

UCSC:O60566 BUB1B

Reference Transcript

RefSeq:NM_001211.5 BUB1B

Other Identifiers

0002320017

11720647_a_at

16799426

203755_at

35699_at

3589700

3589701

3589702

3589704

3589706

3589707

3589710

3589712

3589713

3589714

3589716

3589718

3589719

3589720

3589721

3589722

3589723

3589725

3589726

3589728

3589729

3589730

3589731

3589732

3589734

3589735

3589737

3589738

3589739

3589740

701

7982663

A_14_P121953

A_23_P163481

GE54489

GO:0000003

GO:0000166

GO:0000228

GO:0000278

GO:0000775

GO:0000776

GO:0000777

GO:0000778

GO:0000940

GO:0003674

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005680

GO:0005694

GO:0005737

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0006464

GO:0006468

GO:0006511

GO:0006915

GO:0007049

GO:0007059

GO:0007093

GO:0007094

GO:0008150

GO:0008219

GO:0009056

GO:0016301

GO:0016310

GO:0016740

GO:0031145

GO:0032991

GO:0043167

GO:0043226

GO:0048471

GO:0051276

GO:0051301

GO:0051754

GO:0140014

GO:1901990

ILMN_1733950

ILMN_1797307

PH_hs_0002907

TC15000276.hg

g5729749_3p_at

Participant Of

hasComponent

input

Formation of the MCC complex

Inferred To

bub1b [cytosol] (Xenopus tropicalis)

BUB1 [cytosol] (Saccharomyces cerevisiae)

Homologues of BUB1B [cytosol] (Caenorhabditis elegans)

Homologues of BUB1B [cytosol] (Drosophila melanogaster)

Homologues of BUB1B [cytosol] (Saccharomyces cerevisiae)

BubR1 [cytosol] (Drosophila melanogaster)

bub1 [cytosol] (Dictyostelium discoideum)

bub1 [cytosol] (Schizosaccharomyces pombe)

Bub1 [cytosol] (Drosophila melanogaster)

bub1bb [cytosol] (Danio rerio)

BUB1B [cytosol] (Bos taurus)

BUB1B [cytosol] (Canis familiaris)

BUB1B [cytosol] (Gallus gallus)

BUB1B [cytosol] (Sus scrofa)

Bub1b [cytosol] (Mus musculus)

Bub1b [cytosol] (Rattus norvegicus)

MAD3 [cytosol] (Saccharomyces cerevisiae)

bub-1 [cytosol] (Caenorhabditis elegans)

san-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001202.4

OpenTargets

ENSG00000156970

HPA

ENSG00000156970-BUB1B

GeneCards

O60566

Ensembl

ENST00000412359, ENSG00000156970, ENSP00000398470, ENST00000287598, ENSP00000287598

PRO

O60566

Orphanet

15384

HMDB Protein

HMDBP01451

PDB

3SI5, 5LCW, 5KHU, 2WVI, 4GGD, 5K6S, 5SWF, 5JJA

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12834 CDC20	3	CDC20 [nucleoplasm] (R-HSA-174112) CDC20 [cytosol] (R-HSA-141412) PolyUb-CDC20 [nucleoplasm] (R-HSA-6783069)	0.972	32
UniProt:O43684 BUB3	1	BUB3 [cytosol] (R-HSA-141416)	0.908	9
UniProt:Q13257 MAD2L1	2	Activated MAD2L1 [cytosol] (R-HSA-141447) MAD2L1 [cytosol] (R-HSA-141400)	0.883	14
UniProt:P30260 CDC27	2	CDC27 [nucleoplasm] (R-HSA-174175) CDC27 [cytosol] (R-HSA-174073)	0.857	6
UniProt:Q92831 KAT2B	1	KAT2B [nucleoplasm] (R-HSA-352430)	0.715	14
UniProt:Q9UJX5 ANAPC4	2	ANAPC4 [cytosol] (R-HSA-174168) ANAPC4 [nucleoplasm] (R-HSA-174115)	0.708	10
UniProt:Q8NG31-2 KNL1			0.703	10
UniProt:O43683 BUB1	1	BUB1 [cytosol] (R-HSA-377888)	0.678	3
UniProt:Q02224 CENPE	1	CENPE [cytosol] (R-HSA-376245)	0.581	4
UniProt:Q8IXJ6 SIRT2	1	SIRT2 [cytosol] (R-HSA-2161118)	0.576	3
UniProt:Q9UJX3 ANAPC7	2	ANAPC7 [cytosol] (R-HSA-174242) ANAPC7 [nucleoplasm] (R-HSA-174204)	0.564	2
UniProt:Q8BGZ4	2	Cdc23 [cytosol] (R-MMU-174137) Cdc23 [nucleoplasm] (R-MMU-174228)	0.564	3
UniProt:Q99JP4	2	Cdc26 [cytosol] (R-MMU-174052) Cdc26 [nucleoplasm] (R-MMU-174216)	0.564	3
UniProt:Q9H081 MIS12	1	MIS12 [cytosol] (R-HSA-375313)	0.564	2
UniProt:Q9Z1B5	1	Mad2l1 [cytosol] (R-MMU-141400)	0.564	2
UniProt:Q9JJ66	3	Cdc20 [nucleoplasm] (R-MMU-174112) Cdc20 [nucleoplasm] (R-MMU-6783069) Cdc20 [cytosol] (R-MMU-141412)	0.564	2
UniProt:Q8R349	2	Cdc16 [cytosol] (R-MMU-174156) Cdc16 [nucleoplasm] (R-MMU-174049)	0.564	2
UniProt:O95229 ZWINT	1	ZWINT [cytosol] (R-HSA-376254)	0.528	2
UniProt:Q9UJX2 CDC23	2	CDC23 [nucleoplasm] (R-HSA-174228) CDC23 [cytosol] (R-HSA-174137)	0.527	2
UniProt:Q13042 CDC16	2	CDC16 [cytosol] (R-HSA-174156) CDC16 [nucleoplasm] (R-HSA-174049)	0.527	2
UniProt:Q8NG31 KNL1	2	CASC5 [cytosol] (R-HSA-375322) CASC5 [nucleoplasm] (R-HSA-606296)	0.527	2
UniProt:Q9H1A4 ANAPC1	2	ANAPC1 [cytosol] (R-HSA-174189) ANAPC1 [nucleoplasm] (R-HSA-174217)	0.527	2
UniProt:P45481 Crebbp	4	Crebbp [nucleoplasm] (R-MMU-556795) Crebbp [nucleoplasm] (R-MMU-193545) Foxo4-S-S-Crebbp [nucleoplasm] (R-MMU-9617719) Sumo1-K999,K1034,K1057-Crebbp [nucleoplasm] (R-MMU-3927936)	0.499	3

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