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BUB1B [cytosol]
Stable Identifier
R-HSA-141436
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
hBUBR1
Icon
Locations in the PathwayBrowser for interactor UniProt:P45481 Crebbp
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
Inactivation of APC/C via direct inhibition of the APC/C complex (Homo sapiens)
Formation of the MCC complex (Homo sapiens)
BUB1B [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
Inactivation of APC/C via direct inhibition of the APC/C complex (Homo sapiens)
Formation of the MCC complex (Homo sapiens)
BUB1B [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60566 BUB1B
Gene Names
BUB1B, BUBR1, MAD3L, SSK1
Chain
chain:1-1050
Reference Genes
BioGPS Gene:701 BUB1B
COSMIC (genes):BUB1B BUB1B
CTD Gene:701 BUB1B
dbSNP Gene:701 BUB1B
ENSEMBL:ENSG00000156970 BUB1B
ENSEMBL_homo_sapiens_GENE:ENSG00000156970.13 BUB1B
HGNC:1149 BUB1B
KEGG Gene (Homo sapiens):701 BUB1B
Monarch:701 BUB1B
NCBI Gene:701 BUB1B
OMIM:602860 BUB1B
UCSC:O60566 BUB1B
Reference Transcript
RefSeq:NM_001211.5 BUB1B
Other Identifiers
11720647_a_at
16799426
203755_PM_at
203755_at
35699_at
3589700
3589701
3589702
3589704
3589706
3589707
3589710
3589712
3589713
3589714
3589716
3589718
3589719
3589720
3589721
3589722
3589723
3589725
3589726
3589728
3589729
3589730
3589731
3589732
3589734
3589735
3589737
3589738
3589739
3589740
701
7982663
A_14_P121953
A_23_P163481
GE54489
GO:0000166
GO:0000278
GO:0000775
GO:0000776
GO:0000940
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005680
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0006915
GO:0007049
GO:0007059
GO:0007091
GO:0007094
GO:0012501
GO:0016301
GO:0016310
GO:0016740
GO:0022414
GO:0023052
GO:0033597
GO:0043226
GO:0048471
GO:0051301
GO:0051754
GO:0071459
GO:0106310
GO:0140013
GO:0140014
GO:0140096
HMNXSV003036813
ILMN_1797307
PH_hs_0002907
TC15000276.hg
g5729749_3p_at
Participates
as a component of
hBUBR1:hBUB3:MAD2* complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Mitotic checkpoint complex [cytosol] (Homo sapiens)
as an input of
Formation of the MCC complex (Homo sapiens)
Inferred To
bub1b [cytosol]
(Xenopus tropicalis)
bub1 [cytosol]
(Dictyostelium discoideum)
BUB1B [cytosol]
(Bos taurus)
BUB1B [cytosol]
(Caenorhabditis elegans)
BUB1B [cytosol]
(Canis familiaris)
BUB1B [cytosol]
(Drosophila melanogaster)
BUB1B [cytosol]
(Gallus gallus)
BUB1B [cytosol]
(Mus musculus)
BUB1B [cytosol]
(Saccharomyces cerevisiae)
BUB1B [cytosol]
(Schizosaccharomyces pombe)
BUB1B [cytosol]
(Sus scrofa)
Bub1b [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_001202.4
Guide to Pharmacology - Targets
1950
OpenTargets
ENSG00000156970
GeneCards
O60566
HPA
ENSG00000156970-BUB1B
Ensembl
ENSP00000287598
,
ENST00000287598
,
ENSP00000398470
,
ENST00000412359
,
ENSG00000156970
PRO
O60566
Pharos - Targets
O60566
Orphanet
15384
HMDB Protein
HMDBP01451
PDB
2WVI
,
5KHU
,
6TLJ
,
5K6S
,
5SWF
,
5LCW
,
5JJA
,
4GGD
,
3SI5
Interactors (28)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q12834 CDC20
3
CDC20 [cytosol]
(R-HSA-141412)
CDC20 [nucleoplasm]
(R-HSA-174112)
PolyUb-CDC20 [nucleoplasm]
(R-HSA-6783069)
0.975
38
UniProt:O43684 BUB3
1
BUB3 [cytosol]
(R-HSA-141416)
0.932
13
UniProt:Q13257 MAD2L1
2
MAD2L1 [cytosol]
(R-HSA-141400)
Activated MAD2L1 [cytosol]
(R-HSA-141447)
0.905
14
UniProt:P30260 CDC27
2
CDC27 [nucleoplasm]
(R-HSA-174175)
CDC27 [cytosol]
(R-HSA-174073)
0.905
8
UniProt:Q9UJX5 ANAPC4
2
ANAPC4 [nucleoplasm]
(R-HSA-174115)
ANAPC4 [cytosol]
(R-HSA-174168)
0.823
12
UniProt:Q13042 CDC16
2
CDC16 [nucleoplasm]
(R-HSA-174049)
CDC16 [cytosol]
(R-HSA-174156)
0.788
5
UniProt:Q9UJX2 CDC23
2
CDC23 [cytosol]
(R-HSA-174137)
CDC23 [nucleoplasm]
(R-HSA-174228)
0.788
5
UniProt:O43683 BUB1
1
BUB1 [cytosol]
(R-HSA-377888)
0.752
5
UniProt:Q9UJX6 ANAPC2
2
ANAPC2 [cytosol]
(R-HSA-174229)
ANAPC2 [nucleoplasm]
(R-HSA-174141)
0.725
4
UniProt:Q92831 KAT2B
1
KAT2B [nucleoplasm]
(R-HSA-352430)
0.715
14
UniProt:Q8NG31-2 KNL1
0.703
10
UniProt:Q9UJX3 ANAPC7
2
ANAPC7 [nucleoplasm]
(R-HSA-174204)
ANAPC7 [cytosol]
(R-HSA-174242)
0.669
3
UniProt:Q9H1A4 ANAPC1
2
ANAPC1 [cytosol]
(R-HSA-174189)
ANAPC1 [nucleoplasm]
(R-HSA-174217)
0.643
3
UniProt:Q96DE5 ANAPC16
2
ANAPC16 [nucleoplasm]
(R-HSA-6805137)
ANAPC16 [cytosol]
(R-HSA-6805138)
0.643
3
UniProt:Q02224 CENPE
1
CENPE [cytosol]
(R-HSA-376245)
0.581
4
UniProt:Q8IXJ6 SIRT2
1
SIRT2 [cytosol]
(R-HSA-2161118)
0.576
3
UniProt:Q8BGZ4
2
Cdc23 [nucleoplasm]
(R-MMU-174228)
Cdc23 [cytosol]
(R-MMU-174137)
0.564
3
UniProt:Q99JP4
2
Cdc26 [nucleoplasm]
(R-MMU-174216)
Cdc26 [cytosol]
(R-MMU-174052)
0.564
3
UniProt:Q9H081 MIS12
1
MIS12 [cytosol]
(R-HSA-375313)
0.564
2
UniProt:Q8R349
2
Cdc16 [nucleoplasm]
(R-MMU-174049)
Cdc16 [cytosol]
(R-MMU-174156)
0.564
2
UniProt:Q9JJ66
3
Cdc20 [nucleoplasm]
(R-MMU-6783069)
Cdc20 [nucleoplasm]
(R-MMU-174112)
Cdc20 [cytosol]
(R-MMU-141412)
0.564
2
UniProt:Q9Z1B5
1
Mad2l1 [cytosol]
(R-MMU-141400)
0.564
2
UniProt:O95229 ZWINT
1
ZWINT [cytosol]
(R-HSA-376254)
0.528
2
UniProt:Q9UJX4 ANAPC5
2
ANAPC5 [nucleoplasm]
(R-HSA-174153)
ANAPC5 [cytosol]
(R-HSA-174211)
0.527
2
UniProt:Q8NG31 KNL1
2
CASC5 [nucleoplasm]
(R-HSA-606296)
CASC5 [cytosol]
(R-HSA-375322)
0.527
2
UniProt:Q8NHZ8 CDC26
2
CDC26 [nucleoplasm]
(R-HSA-174216)
CDC26 [cytosol]
(R-HSA-174052)
0.527
2
UniProt:O95816 BAG2
1
BAG2 [cytosol]
(R-HSA-5255445)
0.527
2
UniProt:P45481 Crebbp
4
CREBBP [nucleoplasm]
(R-MMU-193545)
Crebbp [nucleoplasm]
(R-MMU-556795)
Foxo4-S-S-Crebbp [nucleoplasm]
(R-MMU-9617719)
monoSumo1-K999,K1034,K1057-Crebbp [nucleoplasm]
(R-MMU-3927936)
0.499
3
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