Release of activated MAD2 from kinetochores

Stable Identifier
R-HSA-141439
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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The mechanism by which the conformationally altered inhibitory form of Mad2 is released from its association with Mad1 at the kinetochore is not known. Mad1 and Cdc20 have a common 10 residue Mad2 binding motif. Therefore, one possibility is that Mad2 is transferred competitively from Mad1 to Cdc20 (Luo et al., 2002; Sironi et al., 2002).

Literature References
PubMed ID Title Journal Year
12006501 Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint

Sironi, L, Mapelli, M, Knapp, S, De Antoni, A, Jeang, KT, Musacchio, A

EMBO J 2002
Participants
Participant Of
Orthologous Events
Authored
Created