Release of activated MAD2 from kinetochores

Stable Identifier
R-HSA-141439
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The mechanism by which the conformationally altered inhibitory form of Mad2 is released from its association with Mad1 at the kinetochore is not known. Mad1 and Cdc20 have a common 10 residue Mad2 binding motif. Therefore, one possibility is that Mad2 is transferred competitively from Mad1 to Cdc20 (Luo et al., 2002; Sironi et al., 2002).
Literature References
PubMed ID Title Journal Year
12006501 Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint

Knapp, S, Sironi, L, Musacchio, A, De Antoni, A, Mapelli, M, Jeang, KT

EMBO J 2002
Participants
Participates
Orthologous Events
Authored
Created
Cite Us!