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Activated MAD2L1 [cytosol]
Stable Identifier
R-HSA-141447
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Icon
Locations in the PathwayBrowser for interactor UniProt:Q14145 KEAP1
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
Mitotic Spindle Checkpoint (Homo sapiens)
Amplification of signal from the kinetochores (Homo sapiens)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
Release of activated MAD2 from kinetochores (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
Inactivation of APC/C via CDC20 sequestration (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Inactivation of APC/C via direct inhibition of the APC/C complex (Homo sapiens)
Formation of the MCC complex (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
Regulation of APC/C activators between G1/S and early anaphase (Homo sapiens)
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components (Homo sapiens)
Inactivation of APC/C via CDC20 sequestration (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
Inactivation of APC/C via direct inhibition of the APC/C complex (Homo sapiens)
Formation of the MCC complex (Homo sapiens)
Activated MAD2L1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13257 MAD2L1
Gene Names
MAD2L1, MAD2
Chain
initiator methionine:, chain:2-205
Reference Genes
BioGPS Gene:4085 MAD2L1
COSMIC (genes):MAD2L1 MAD2L1
CTD Gene:4085 MAD2L1
dbSNP Gene:4085 MAD2L1
ENSEMBL:ENSG00000164109 MAD2L1
ENSEMBL_homo_sapiens_GENE:ENSG00000164109.14 MAD2L1
HGNC:6763 MAD2L1
KEGG Gene (Homo sapiens):4085 MAD2L1
Monarch:4085 MAD2L1
NCBI Gene:4085 MAD2L1
OMIM:601467 MAD2L1
UCSC:Q13257 MAD2L1
Reference Transcript
RefSeq:NM_002358.3 MAD2L1
Other Identifiers
11720185_a_at
11720186_s_at
11748136_a_at
1554768_PM_a_at
1554768_a_at
16979389
1721_g_at
203362_PM_s_at
203362_s_at
236312_PM_at
236312_at
2783726
2783727
2783728
2783729
2783730
2783731
2783732
2783733
2783734
2783735
2783736
2783737
2783739
2783742
2783743
2783744
3538716
3538718
3538720
3538721
3538722
37282_at
4085
46436_at
55824_at
8102560
A_23_P92441
GE59318
GO:0000070
GO:0000132
GO:0000278
GO:0000775
GO:0000776
GO:0000922
GO:0005515
GO:0005634
GO:0005635
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0005856
GO:0007010
GO:0007049
GO:0007059
GO:0007094
GO:0007163
GO:0012501
GO:0023052
GO:0030163
GO:0033597
GO:0036211
GO:0042177
GO:0042802
GO:0042803
GO:0043066
GO:0043226
GO:0044615
GO:0045930
GO:0048471
GO:0051301
GO:0051660
GO:0072686
GO:0090267
GO:0140014
GO:1904667
GO:1990728
HMNXSV003035103
Hs.44380.0.A1_3p_at
Hs2.79078.2.S1_3p_s_at
ILMN_1777564
ILMN_2112460
TC04001507.hg
U65410_at
g6466452_3p_s_at
Participates
as a component of
MAD2*CDC20 complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2* complex [cytosol] (Homo sapiens)
hBUBR1:hBUB3:MAD2*:CDC20 complex [cytosol] (Homo sapiens)
Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
as an input of
Inactivation of APC/C via CDC20 sequestration (Homo sapiens)
Formation of the MCC complex (Homo sapiens)
as an output of
Release of activated MAD2 from kinetochores (Homo sapiens)
Other forms of this molecule
MAD2L1 [cytosol]
Inferred To
Mad2l1 [cytosol]
(Mus musculus)
Mad2l1 [cytosol]
(Rattus norvegicus)
mad2l1-1 [cytosol]
(Dictyostelium discoideum)
MAD2L1 [cytosol]
(Bos taurus)
MAD2L1 [cytosol]
(Canis familiaris)
MAD2L1 [cytosol]
(Gallus gallus)
MAD2L1 [cytosol]
(Sus scrofa)
mdf-2 [cytosol]
(Caenorhabditis elegans)
MAD2 [cytosol]
(Saccharomyces cerevisiae)
mad2 [cytosol]
(Drosophila melanogaster)
mad2 [cytosol]
(Schizosaccharomyces pombe)
mad2l1 [cytosol]
(Danio rerio)
mad2l1 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_002349.1
OpenTargets
ENSG00000164109
GeneCards
Q13257
HPA
ENSG00000164109-MAD2L1
Ensembl
ENST00000333047
,
ENSP00000332295
,
ENSP00000296509
,
ENSG00000164109
,
ENST00000296509
PRO
Q13257
Pharos - Targets
Q13257
PDB
1GO4
,
3GMH
,
2V64
,
2QYF
,
1DUJ
,
5KHU
,
5LCW
,
6TLJ
,
1KLQ
,
1S2H
,
2VFX
,
6F0X
Interactors (28)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q12834 CDC20
3
CDC20 [cytosol]
(R-HSA-141412)
CDC20 [nucleoplasm]
(R-HSA-174112)
PolyUb-CDC20 [nucleoplasm]
(R-HSA-6783069)
0.982
38
UniProt:Q9Y6D9 MAD1L1
1
MAD1L1 [cytosol]
(R-HSA-141433)
0.982
50
UniProt:Q15013 MD2BP
0.961
20
UniProt:P30260 CDC27
2
CDC27 [nucleoplasm]
(R-HSA-174175)
CDC27 [cytosol]
(R-HSA-174073)
0.914
10
UniProt:O60566 BUB1B
1
BUB1B [cytosol]
(R-HSA-141436)
0.905
14
UniProt:Q13257 MAD2L1
2
MAD2L1 [cytosol]
(R-HSA-141400)
Activated MAD2L1 [cytosol]
(R-HSA-141447)
0.889
9
UniProt:Q14145 KEAP1
3
Ub-KEAP1 [cytosol]
(R-HSA-6782766)
ub-KEAP1 [cytosol]
(R-HSA-9766647)
KEAP1 [cytosol]
(R-HSA-976038)
0.831
8
UniProt:Q9Y3Q8 T22D4
0.801
8
UniProt:Q562F6 SGO2
1
SGOL2 [cytosol]
(R-HSA-376242)
0.731
11
UniProt:Q9UJX5 ANAPC4
2
ANAPC4 [nucleoplasm]
(R-HSA-174115)
ANAPC4 [cytosol]
(R-HSA-174168)
0.725
7
UniProt:P06213 INSR
6
p-6Y-INSR(763-1382) [endosome membrane]
(R-HSA-141719)
INSR(763-1382) [endosome membrane]
(R-HSA-141722)
INSR(28-758) [endosome membrane]
(R-HSA-141718)
INSR(763-1382) [plasma membrane]
(R-HSA-74669)
p-6Y-INSR(763-1382) [plasma membrane]
(R-HSA-74670)
INSR(28-758) [plasma membrane]
(R-HSA-74668)
0.701
4
IntAct:EBI-1563533 MAD2 PEPTIDE
0.667
3
UniProt:Q7L775 EPMIP
0.666
4
UniProt:P78536 ADAM17
6
ADAM17 [endoplasmic reticulum lumen]
(R-HSA-9662763)
ADAM17(215-827) [Golgi membrane]
(R-HSA-9662839)
ADAM17(1-214) [Golgi membrane]
(R-HSA-9662784)
ADAM17 [Golgi membrane]
(R-HSA-9662835)
ADAM17(215-827) [plasma membrane]
(R-HSA-9663048)
ADAM17 [plasma membrane]
(R-HSA-179878)
0.581
3
UniProt:Q8BGZ4
2
Cdc23 [nucleoplasm]
(R-MMU-174228)
Cdc23 [cytosol]
(R-MMU-174137)
0.564
2
UniProt:Q9DCX1 MD2BP
0.564
2
UniProt:Q8R349
2
Cdc16 [nucleoplasm]
(R-MMU-174049)
Cdc16 [cytosol]
(R-MMU-174156)
0.564
2
UniProt:Q9JJ66
3
Cdc20 [nucleoplasm]
(R-MMU-6783069)
Cdc20 [nucleoplasm]
(R-MMU-174112)
Cdc20 [cytosol]
(R-MMU-141412)
0.564
2
UniProt:P06213-2 INSR
0.556
3
UniProt:O75140-2 DEPDC5
0.556
3
IntAct:EBI-25890541 CCSB
0.556
3
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [cytosol]
(R-HSA-373639)
0.556
3
UniProt:Q13042 CDC16
2
CDC16 [nucleoplasm]
(R-HSA-174049)
CDC16 [cytosol]
(R-HSA-174156)
0.527
3
UniProt:Q9Y2K7 KDM2A
1
KDM2A [nucleoplasm]
(R-HSA-3214392)
0.527
3
UniProt:Q9H1A4 ANAPC1
2
ANAPC1 [cytosol]
(R-HSA-174189)
ANAPC1 [nucleoplasm]
(R-HSA-174217)
0.527
2
UniProt:Q9UJX2 CDC23
2
CDC23 [cytosol]
(R-HSA-174137)
CDC23 [nucleoplasm]
(R-HSA-174228)
0.527
2
UniProt:Q5JTV8 TOR1AIP1
1
TOR1AIP1 [cytosol]
(R-HSA-9715083)
0.527
2
UniProt:O95235 KIF20A
3
KIF20A [cytosol]
(R-HSA-1015868)
p-S528-KIF20A [nucleoplasm]
(R-HSA-156685)
KIF20A [nucleoplasm]
(R-HSA-156721)
0.527
2
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