Reactome | INSR(28-758) [endosome membrane]

INSR(28-758) [endosome membrane]

Stable Identifier

R-HSA-141718

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome membrane

Synonyms

Insulin receptor alpha subunit, INSR

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External Reference Information

External Reference

UniProt:P06213 INSR

Gene Names

INSR

Chain

signal peptide:1-27, chain:28-758, chain:763-1382

Reference Genes

BioGPS Gene:3643 INSR

COSMIC (genes):INSR INSR

CTD Gene:3643 INSR

dbSNP Gene:3643 INSR

ENSEMBL:ENSG00000171105 INSR

HGNC:6091 INSR

KEGG:hsa:3643 INSR

Monarch:3643 INSR

NCBI Gene:3643 INSR

OMIM:147670 INSR

UCSC:P06213 INSR

Reference Transcript

Participates

as a component of

Other forms of this molecule

INSR(28-758) [plasma membrane]

p-6Y-INSR(763-1382) [plasma membrane]

INSR(763-1382) [plasma membrane]

INSR(763-1382) [endosome membrane]

p-6Y-INSR(763-1382) [endosome membrane]

Inferred To

INSR [endosome membrane] (Canis familiaris)

INSR [endosome membrane] (Gallus gallus)

INSR(28-758) [endosome membrane] (Bos taurus)

INSR(28-758) [endosome membrane] (Caenorhabditis elegans)

INSR(28-758) [endosome membrane] (Danio rerio)

INSR(28-758) [endosome membrane] (Drosophila melanogaster)

INSR(28-758) [endosome membrane] (Mus musculus)

INSR(28-758) [endosome membrane] (Rattus norvegicus)

INSR(28-758) [endosome membrane] (Sus scrofa)

INSR(28-758) [endosome membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_000199.2, NP_001073285.1

Guide to Pharmacology - Targets

1800

OpenTargets

ENSG00000171105

ENSEMBL

ENSP00000303830, ENSG00000171105, ENST00000302850, ENST00000341500, ENSP00000342838

ZINC - FDA approved

INSR_HUMAN

ZINC - Substances

INSR_HUMAN

ZINC - Biogenic

INSR_HUMAN

ZINC target

P06213

PRO

P06213

GlyGen

P06213

PDB

8DWN, 3W11, 2Z8C, 7BW7, 3W12, 7U6E, 8VJB, 7BWA, 2B4S, 7MQS, 8U4B, 1IRK, 5HHW, 7PG0, 6VEP, 7MQO, 7PG2, 2HR7, 4ZXB, 7U6D, 5KQV, 3EKK, 7S0Q, 1P14, 3EKN, 6PXW, 8GUY, 1RQQ, 4IBM, 7S8V, 6HN4, 3BU3, 3BU6, 2MFR, 5U1M, 1I44, 4XSS, 7BW8, 3W13, 5E1S, 5J3H, 7PG3, 6VEQ, 7PG4, 7QID, 6SOF, 7MQR, 7YQ6, 8VJC, 8U4C, 7YQ5, 8U4E, 7YQ3, 7YQ4, 4OGA, 7PHT, 6PXV, 1IR3, 1GAG, 2AUH, 6HN5, 7KD6, 3ETA, 3BU5, 4XLV, 4XST

ZINC - Investigational

INSR_HUMAN

ZINC - Metabolites

INSR_HUMAN

HPA

ENSG00000171105-INSR

GeneCards

INSR

Pharos - Targets

P06213

Orphanet

INSR

ZINC - Predictions - Purchasable

INSR_HUMAN

HMDB Protein

HMDBP01521

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P18031 PTPN1	2	PTPN1 [endosome membrane] (R-HSA-9815895) PTPN1 [cytosol] (R-HSA-210625)	0.98	33
UniProt:P19174 PLCG1	6	p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.799	9
UniProt:P35570 Irs1	7	Irs1 [cytosol] (R-RNO-1168867) phospho-Irs1 [plasma membrane] (R-RNO-2445090) Irs1 [plasma membrane] (R-RNO-2425392) p-Y-Irs1 [cytosol] (R-RNO-112362) Irs1 [cytosol] (R-RNO-74769) phospho-Irs1 [cytosol] (R-RNO-74772) phospho-Irs1 [plasma membrane] (R-RNO-198366)	0.791	5
UniProt:P27986 PIK3R1	16	PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) p-Y-PIK3R1 [cytosol] (R-HSA-9680647)	0.767	5
UniProt:P35568 IRS1	5	p-Y-IRS1 [plasma membrane] (R-HSA-198366) p-Y-IRS1 [cytosol] (R-HSA-74772) IRS1 [cytosol] (R-HSA-74769) IRS1 [plasma membrane] (R-HSA-2425392) p-6Y-IRS1 [plasma membrane] (R-HSA-2445090)	0.704	5
UniProt:Q13257 MAD2L1	2	MAD2L1 [cytosol] (R-HSA-141400) Activated MAD2L1 [cytosol] (R-HSA-141447)	0.701	4
UniProt:Q06124 PTPN11	4	p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573) PTPN11 [cytosol] (R-HSA-162563) PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y542-PTPN11 [cytosol] (R-HSA-1369081)	0.65	3
UniProt:Q15262 PTPRK	1	PTPRK [plasma membrane] (R-HSA-6785699)	0.59	2
UniProt:Q13322 GRB10	2	GRB10 [cytosol] (R-HSA-110009) p-Y GRB10 [cytosol] (R-HSA-9706168)	0.581	4
UniProt:P29353 SHC1	5	p-Y-SHC1 [cytosol] (R-HSA-162568) SHC1 [cytosol] (R-HSA-74680) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y427-SHC1 [cytosol] (R-HSA-74684)	0.573	2
UniProt:Q9Y4L1 HYOU1	3	HYOU1 [endoplasmic reticulum lumen] (R-HSA-535542) HYOU1 [endocytic vesicle lumen] (R-HSA-3221924) HYOU1 [extracellular region] (R-HSA-3221939)	0.569	3
UniProt:Q9Y4H2 IRS2	4	IRS2 [plasma membrane] (R-HSA-2428927) IRS2 [cytosol] (R-HSA-57528) p-Y-IRS2 [cytosol] (R-HSA-74774) p-Y-IRS2 [plasma membrane] (R-HSA-198334)	0.527	4
UniProt:Q99490 AGAP2	1	AGAP2 [cytosol] (R-HSA-622355)	0.524	2

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