Processing of SCF isoform 1

Stable Identifier
R-HSA-1433374
Type
Reaction
Species
Homo sapiens
Compartment
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SCF exists as two alternatively spliced variants, a soluble form and a membrane-bound form differing in one exon (exon 6). Both isoforms are initially membrane bound with an extracellular domain, a transmembrane segment and an intracellular region. The longer isoform is rapidly cleaved to generate a 165 aa soluble protein knows as sSCF. The SCF transcript that lacks exon 6 encodes a glycoprotein that remains membrane-bound (mSCF). Both mSCF and sSCF are bioactive but different in their efficacy in c-kit activation.
Proteases including matrix metalloprotease-9 (Heissig et al., 2002), Chymase-1 (Longley et al., 1997) and several members of the ADAMs family (Kawaguchi et al, 2007; Amour et al, 2002; Chesneau et al, 2003; Mohan et al, 2002; Roghani et al, 1999; Zou et al, 2004) have been suggested to have a role in the processing of sSCF.

Literature References
PubMed ID Title Journal Year
17344430 Different ADAMs have distinct influences on Kit ligand processing: phorbol-ester-stimulated ectodomain shedding of Kitl1 by ADAM17 is reduced by ADAM19

Kawaguchi, N, Horiuchi, K, Becherer, JD, Toyama, Y, Besmer, P, Blobel, CP

J Cell Sci 2007
9256427 Chymase cleavage of stem cell factor yields a bioactive, soluble product

Longley, BJ, Tyrrell, L, Ma, Y, Williams, DA, Halaban, R, Langley, K, Lu, HS, Schechter, NM

Proc Natl Acad Sci U S A 1997
15526160 Signal transduction via the stem cell factor receptor/c-Kit

Rönnstrand, L

Cell Mol Life Sci 2004
12062105 Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand

Heissig, B, Hattori, K, Dias, S, Friedrich, M, Ferris, B, Hackett, NR, Crystal, RG, Besmer, P, Lyden, D, Moore, MA, Werb, Z, Rafii, S

Cell 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of Endopeptidases for SCF processing [extracellular region]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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