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SOCS1 as a regulator of KIT signaling
Stable Identifier
R-HSA-1433410
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
extracellular region
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by SCF-KIT (Homo sapiens)
Regulation of KIT signaling (Homo sapiens)
SOCS1 as a regulator of KIT signaling (Homo sapiens)
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SOCS1 has been identified as a KIT binding partner from the yeast two-hybrid system (Sepulveda et al, 1999). SOCS1 expression is induced upon KIT activation. It associates with KIT via its SH2 domain. SOCS1 does not inhibit KIT kinase activity directly, instead it binds to GRB2 and VAV1, and selectively inhibits SCF-induced proliferation, while not effecting survival signal (Sepulveda et al, 1999). It has been proposed that SOCS1 may interrupt signal transduction pathways downstream of JAK2 (Sepulveda et al, 1999).
Participants
Input
p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane]
(Homo sapiens)
SOCS1 [cytosol]
(Homo sapiens)
Output
SOCS1:p-KIT complex [plasma membrane]
(Homo sapiens)
Participates
as an event of
Regulation of KIT signaling (Homo sapiens)
Inferred From
Socs1 as a regulator of kit signaling (Mus musculus)
Authored
Garapati, P V (2011-07-11)
Reviewed
Rönnstrand, L (2011-08-22)
Created
Garapati, P V (2011-07-11)
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