Phosphorylation of GAB2 by SFKs

Stable Identifier
R-HSA-1433454
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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Phosphorylation of GAB2 by SFKs
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GAB2 bound to GRB2 on KIT is then phosphorylated on a number of tyrosine residues through the action of Src family kinases (SFKs).
Literature References
PubMed ID Title Journal Year
18697750 Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit

Sun, J, Pedersen, M, Rönnstrand, L

J Biol Chem 2008
Participants
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Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane]

Physical Entity
GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Phosphorylation of GAB2 by SFKs (Bos taurus)
Phosphorylation of GAB2 by SFKs (Canis familiaris)
Phosphorylation of GAB2 by SFKs (Gallus gallus)
Phosphorylation of GAB2 by SFKs (Mus musculus)
Phosphorylation of GAB2 by SFKs (Rattus norvegicus)
Phosphorylation of GAB2 by SFKs (Sus scrofa)
Phosphorylation of GAB2 by SFKs (Xenopus tropicalis)
Authored
Garapati, P V  (2011-07-11)
Reviewed
Rönnstrand, L  (2011-08-22)
Created
Garapati, P V  (2011-07-11)
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