Reactome | MATK [cytosol]

MATK [cytosol]

Stable Identifier

R-HSA-1433581

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

CHK, Megakaryocyte-associated tyrosine-protein kinase, MATK_HUMAN, Csk homologous kinase

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P42679 MATK

Gene Names

MATK, CTK, HYL

Chain

chain:1-507

Reference Genes

BioGPS Gene:4145 MATK

COSMIC (genes):MATK MATK

CTD Gene:4145 MATK

dbSNP Gene:4145 MATK

ENSEMBL:ENSG00000007264 MATK

HGNC:6906 MATK

KEGG:hsa:4145 MATK

Monarch:4145 MATK

NCBI Gene:4145 MATK

OMIM:600038 MATK

UCSC:P42679 MATK

Reference Transcript

Other Identifiers

11731227_a_at

16867153

206267_PM_s_at

206267_s_at

36264_at

3846404

3846405

3846406

3846407

3846408

3846409

3846410

3846411

3846412

3846413

3846414

3846415

3846416

3846417

3846418

3846419

3846420

3846421

3846422

3846423

3846424

3846425

3846426

3846427

3846428

3846429

3846430

3846431

3846432

3846433

3846434

3846435

3846436

3846438

3846440

3846442

4145

8032682

A_23_P50678

GE88095

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0005886

GO:0006468

GO:0008284

GO:0016020

GO:0016740

GO:0140096

HMNXSV003019498

ILMN_1669321

ILMN_1803615

ILMN_2319000

PH_hs_0025640

S75168_rna1_at

TC19001051.hg

g4505108_3p_a_at

Participates

as a component of

p-ERBB2 heterodimers:MATK [plasma membrane] (Homo sapiens)

as an input of

MATK (CSK homologous kinase) binds phosphorylated ERBB2 (Homo sapiens)

Inferred To

MATK [cytosol] (Bos taurus)

MATK [cytosol] (Caenorhabditis elegans)

MATK [cytosol] (Canis familiaris)

MATK [cytosol] (Drosophila melanogaster)

MATK [cytosol] (Gallus gallus)

MATK [cytosol] (Mus musculus)

MATK [cytosol] (Rattus norvegicus)

MATK [cytosol] (Sus scrofa)

Homologues of MATK [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_002369.2, NP_647611.1, NP_647612.1, XP_011526320.1

ZINC - World Drugs

MATK_HUMAN

Guide to Pharmacology - Targets

2101

OpenTargets

ENSG00000007264

ENSEMBL

ENSP00000308734, ENST00000395040, ENST00000619596, ENSP00000483213, ENST00000395045, ENSP00000378481, ENST00000310132, ENSP00000378485

ZINC - FDA approved

MATK_HUMAN

ZINC - Substances

MATK_HUMAN

ZINC - Biogenic

MATK_HUMAN

ZINC target

P42679

PRO

P42679

PDB

1JWO, 3US4, 1X6G

ZINC - Investigational

MATK_HUMAN

HPA

ENSG00000007264-MATK

Pharos - Targets

P42679

ZINC - Predictions - Purchasable

MATK_HUMAN

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.623	2
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.59	2
UniProt:Q92876 KLK6			0.556	3
UniProt:Q9Y5Z0 BACE2			0.556	3
UniProt:P41240 CSK	2	CSK [cytosol] (R-HSA-203776) CSK [plasma membrane] (R-HSA-180499)	0.527	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.524	2
UniProt:O43559 FRS3	3	p-5Y-FRS3 [plasma membrane] (R-HSA-191475) FRS3 [plasma membrane] (R-HSA-191482) p-Y-FRS3 [plasma membrane] (R-HSA-9032427)	0.488	2
UniProt:Q14289 PTK2B	3	PTK2B [cytosol] (R-HSA-390932) PTK2B [cytosol] (R-HSA-5218721) p-Y-PTK2B [cytosol] (R-HSA-508515)	0.462	2

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