Regulation of signaling by NODAL

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R-HSA-1433617
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Pathway
Species
Homo sapiens
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Mature NODAL can form heterodimers with LEFTY1, LEFTY2, or CERBERUS. The heterodimers do not activate the NODAL receptor. LEFTY1 and LEFTY2 also bind CRIPTO and CRYPTIC coreceptors and prevent them from interacting with other components of the NODAL receptor. By these mechanisms LEFTY1, LEFTY2, and CERBERUS negatively regulate NODAL signaling (reviewed in Shen 2007, Schier 2009).

Literature References
PubMed ID Title Journal Year
20066122 Nodal morphogens

Schier, AF

Cold Spring Harb Perspect Biol 2009
17287255 Nodal signaling: developmental roles and regulation

Shen, MM

Development 2007
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