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MMP7(95-267) [extracellular region]
Stable Identifier
R-HSA-1442479
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Matrilysin-1, MMP7_HUMAN
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Collagen formation (Homo sapiens)
Assembly of collagen fibrils and other multimeric structures (Homo sapiens)
Release of endostatin-like peptides (Homo sapiens)
Endostatin releasing proteases [extracellular region] (Homo sapiens)
MMP7(95-267) [extracellular region] (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Activation of Matrix Metalloproteinases (Homo sapiens)
Activation of MMP9 intermediate form by MMPs (Homo sapiens)
MMP1 (2, 3, 7, 10, 13) [extracellular region] (Homo sapiens)
MMP7(95-267) [extracellular region] (Homo sapiens)
Activation of proMMP7 by MMP3 (Homo sapiens)
MMP7(95-267) [extracellular region] (Homo sapiens)
Autocatalytic activation of MMP7 (Homo sapiens)
MMP7(95-267) [extracellular region] (Homo sapiens)
Full activation of MMP1 (Homo sapiens)
MMP2,3,7,10,11 [extracellular region] (Homo sapiens)
MMP7(95-267) [extracellular region] (Homo sapiens)
Initial activation of proMMP2 by MMP1, 7 (Homo sapiens)
MMP1,7 [extracellular region] (Homo sapiens)
MMP7(95-267) [extracellular region] (Homo sapiens)
Initial activation of proMMP9 by MMPs (Homo sapiens)
MMP1 (2, 3, 7, 10, 13) [extracellular region] (Homo sapiens)
MMP7(95-267) [extracellular region] (Homo sapiens)
Aggrecan degradation by MMP1,2,3,7,9,12,13 (Homo sapiens)
MMP1,2,3,7,9,12,13 [extracellular region] (Homo sapiens)
MMP7(95-267) [extracellular region] (Homo sapiens)
Brevican degradation by MMP1, 2, 3, 7,8,10,13,19 (Homo sapiens)
MMP1, 2, 3, 7,8,10,13,19 [extracellular region] (Homo sapiens)
MMP7(95-267) [extracellular region] (Homo sapiens)
Collagen degradation (Homo sapiens)
Collagen type IV degradation by MMP2,3,4,9,10,12 (Homo sapiens)
MMP2,3,4,9,10,12 [extracellular region] (Homo sapiens)
MMP7(95-267) [extracellular region] (Homo sapiens)
Collagen type XVIII endostatin release (Homo sapiens)
Endostatin-releasing proteases [extracellular region] (Homo sapiens)
MMP7(95-267) [extracellular region] (Homo sapiens)
Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13 (Homo sapiens)
MMP1-3, 7-9, 12, 13 [extracellular region] (Homo sapiens)
MMP7(95-267) [extracellular region] (Homo sapiens)
DCN (decorin) degradation by MMP2, MMP3, MMP7 (Homo sapiens)
MMP2, MMP3, MMP7 [extracellular region] (Homo sapiens)
MMP7(95-267) [extracellular region] (Homo sapiens)
E-cadherin degradation by MMP3, MMP7 and plasmin (Homo sapiens)
MMP3, MMP7, Plasmin [extracellular region] (Homo sapiens)
MMP7(95-267) [extracellular region] (Homo sapiens)
Elastin degradation by elastin-degrading extracellular proteinases (Homo sapiens)
Elastin-degrading extracellular proteinases [extracellular region] (Homo sapiens)
MMP7(95-267) [extracellular region] (Homo sapiens)
Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS (Homo sapiens)
MMP1, 3, 7, 12, 13, 19, CTSS [extracellular region] (Homo sapiens)
MMP7(95-267) [extracellular region] (Homo sapiens)
Laminin-332 degradation by laminin-322 degrading extracellular proteinases (Homo sapiens)
Laminin-332 degrading extracellular proteinases [extracellular region] (Homo sapiens)
MMP7(95-267) [extracellular region] (Homo sapiens)
MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin (Homo sapiens)
Alpha 2-macroglobulin:MMP1, 3, 13, (2, 7-12, 19) [extracellular region] (Homo sapiens)
MMP1, 3, 13, (2, 7-12, 19) [extracellular region] (Homo sapiens)
MMP7(95-267) [extracellular region] (Homo sapiens)
MMP1, 3, 13, (2, 7-12, 19) [extracellular region] (Homo sapiens)
MMP7(95-267) [extracellular region] (Homo sapiens)
MMP2, MMP7, MMP9 bind CD44 (Homo sapiens)
CD44:MMP2, MMP7, MMP9 [plasma membrane] (Homo sapiens)
MMP2, MMP7, MMP9 [extracellular region] (Homo sapiens)
MMP7(95-267) [extracellular region] (Homo sapiens)
MMP2, MMP7, MMP9 [extracellular region] (Homo sapiens)
MMP7(95-267) [extracellular region] (Homo sapiens)
MMP7 cleaves OPTC (Homo sapiens)
MMP7(95-267) [extracellular region] (Homo sapiens)
NID1 degradation by MMP3, 7 (Homo sapiens)
MMP3, MMP7 [extracellular region] (Homo sapiens)
MMP7(95-267) [extracellular region] (Homo sapiens)
OPN (osteopontin) degradation by MMP3, MMP7 (Homo sapiens)
MMP3, MMP7 [extracellular region] (Homo sapiens)
MMP7(95-267) [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Extra-nuclear estrogen signaling (Homo sapiens)
MMPs cleave HB-EGF (Homo sapiens)
MMP2,3,7,9 [extracellular region] (Homo sapiens)
MMP7(95-267) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P09237 MMP7
Gene Names
MMP7, MPSL1, PUMP1
Chain
signal peptide:1-17, propeptide:18-94, chain:95-267
Reference Genes
BioGPS Gene:4316 MMP7
COSMIC (genes):MMP7 MMP7
CTD Gene:4316 MMP7
dbSNP Gene:4316 MMP7
ENSEMBL:ENSG00000137673 MMP7
ENSEMBL_homo_sapiens_GENE:ENSG00000137673.9 MMP7
HGNC:7174 MMP7
KEGG Gene (Homo sapiens):4316 MMP7
Monarch:4316 MMP7
NCBI Gene:4316 MMP7
OMIM:178990 MMP7
UCSC:P09237 MMP7
Reference Transcript
RefSeq:NM_002423.4 MMP7
Other Identifiers
11744030_a_at
11744031_at
11756074_a_at
16743647
204259_PM_at
204259_at
3388674
3388675
3388676
3388677
3388678
3388681
3388682
3388683
3388684
3388685
3388686
4316
668_s_at
7951217
A_23_P52761
GE60350
GO:0003824
GO:0004175
GO:0004222
GO:0004252
GO:0005515
GO:0005576
GO:0005615
GO:0006508
GO:0006509
GO:0008233
GO:0008237
GO:0008270
GO:0016787
GO:0022617
GO:0030198
GO:0030312
GO:0030335
GO:0030574
GO:0031012
GO:0031293
GO:0043226
GO:0046872
GO:0048870
GO:0070062
GO:0140096
HMNXSV003056491
ILMN_1685403
ILMN_2192072
L22524_s_at
PH_hs_0027041
TC11002228.hg
Participates
as an output of
Autocatalytic activation of MMP7 (Homo sapiens)
Activation of proMMP7 by MMP3 (Homo sapiens)
as a member of
MMP2,3,7,10,11 [extracellular region] (Homo sapiens)
MMP1,7 [extracellular region] (Homo sapiens)
MMP3, MMP7 [extracellular region] (Homo sapiens)
MMP1,2,3,7,9,12,13 [extracellular region] (Homo sapiens)
MMP2, MMP3, MMP7 [extracellular region] (Homo sapiens)
MMP2, MMP7, MMP9 [extracellular region] (Homo sapiens)
MMP1, 3, 7, 12, 13, 19, CTSS [extracellular region] (Homo sapiens)
Laminin-332 degrading extracellular proteinases [extracellular region] (Homo sapiens)
MMP1, 2, 3, 7,8,10,13,19 [extracellular region] (Homo sapiens)
Elastin-degrading extracellular proteinases [extracellular region] (Homo sapiens)
MMP1-3, 7-9, 12, 13 [extracellular region] (Homo sapiens)
MMP2,3,4,9,10,12 [extracellular region] (Homo sapiens)
Endostatin-releasing proteases [extracellular region] (Homo sapiens)
MMP3, MMP7, Plasmin [extracellular region] (Homo sapiens)
as a candidate of
Endostatin releasing proteases [extracellular region] (Homo sapiens)
MMP1 (2, 3, 7, 10, 13) [extracellular region] (Homo sapiens)
MMP2,3,7,9 [extracellular region] (Homo sapiens)
MMP1, 3, 13, (2, 7-12, 19) [extracellular region] (Homo sapiens)
Other forms of this molecule
MMP7(18-94) [extracellular region]
MMP7(51-94) [extracellular region]
MMP7(18-50) [extracellular region]
MMP7(18-267) [extracellular region]
MMP7(51-267) [extracellular region]
Inferred To
Homologues of MMP7(95-267) [extracellular region]
(Caenorhabditis elegans)
Homologues of MMP7(95-267) [extracellular region]
(Drosophila melanogaster)
Homologues of MMP7(95-267) [extracellular region]
(Gallus gallus)
Homologues of MMP7(95-267) [extracellular region]
(Xenopus tropicalis)
MMP7(95-267) [extracellular region]
(Bos taurus)
MMP7(95-267) [extracellular region]
(Caenorhabditis elegans)
MMP7(95-267) [extracellular region]
(Canis familiaris)
MMP7(95-267) [extracellular region]
(Danio rerio)
MMP7(95-267) [extracellular region]
(Drosophila melanogaster)
MMP7(95-267) [extracellular region]
(Gallus gallus)
MMP7(95-267) [extracellular region]
(Mus musculus)
MMP7(95-267) [extracellular region]
(Rattus norvegicus)
MMP7(95-267) [extracellular region]
(Sus scrofa)
MMP7(95-267) [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
NP_002414.1
ZINC - World Drugs
MMP7_HUMAN
Guide to Pharmacology - Targets
1631
OpenTargets
ENSG00000137673
ZINC - Substances
MMP7_HUMAN
ZINC target
P09237
PRO
P09237
PDB
1MMR
,
2MZI
,
8JUF
,
5UE5
,
2Y6D
,
8JUD
,
2MZH
,
1MMQ
,
5UE2
,
7WXX
,
2Y6C
,
1MMP
,
2MZE
,
8K4Z
,
2DDY
,
8JUG
ZINC - Investigational
MMP7_HUMAN
GeneCards
P09237
HPA
ENSG00000137673-MMP7
Ensembl
ENSG00000137673
,
ENSP00000260227
,
ENST00000260227
Pharos - Targets
P09237
ZINC - Predictions - Purchasable
MMP7_HUMAN
HMDB Protein
HMDBP02928
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96LI5 CNOT6L
1
CNOT6L [cytosol]
(R-HSA-430027)
0.527
3
UniProt:Q9UIV1 CNOT7
1
CNOT7 [cytosol]
(R-HSA-429877)
0.527
3
UniProt:O75175 CNOT3
1
CNOT3 [cytosol]
(R-HSA-429872)
0.527
3
UniProt:Q9UKZ1 CNOT11
1
CNOT11 [cytosol]
(R-HSA-429981)
0.527
3
UniProt:Q92600 RQCD1
2
RQCD1 [cytosol]
(R-HSA-430029)
RQCD1 [nucleoplasm]
(R-HSA-6810130)
0.527
3
UniProt:Q9UL63 MKLN1
1
Muskelin [cytosol]
(R-HSA-9861557)
0.527
2
UniProt:Q9UFF9 CNOT8
1
CNOT8 [cytosol]
(R-HSA-429979)
0.527
2
UniProt:Q9C0C2 TNKS1BP1
1
TNKS1BP1 [cytosol]
(R-HSA-430011)
0.527
3
UniProt:Q9NWU2 GID8
1
GID8 [cytosol]
(R-HSA-9861665)
0.527
2
UniProt:P17931 LGALS3
3
LGALS3 [ficolin-1-rich granule membrane]
(R-HSA-6803307)
LGALS3 [secretory granule membrane]
(R-HSA-6803327)
LGALS3 [plasma membrane]
(R-HSA-879445)
0.489
5
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