Reactome | YWHAH [cytosol]

YWHAH [cytosol]

Stable Identifier

R-HSA-1445107

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

14-3-3 eta, 14-3-3 protein eta, 1433F_HUMAN

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G2/M Checkpoints (Homo sapiens)
    - G2/M DNA damage checkpoint (Homo sapiens)
      - Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Homo sapiens)
        
        Association of p-S216-CDC25C with 14-3-3 proteins (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)
        
        p-S216-CDC25C:14-3-3 protein complex [cytosol] (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-1 Infection (Homo sapiens)
        
        SARS-CoV-1-host interactions (Homo sapiens)
        
        SARS-CoV-1 targets host intracellular signalling and regulatory pathways (Homo sapiens)
        
        SARS-CoV-1 SUMO1-K62-p-S177-N dimer binds to 14-3-3 proteins (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)
        
        14-3-3 dimer:SUMO1-K62-p-S177-Ncap dimer [cytosol] (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 targets host intracellular signalling and regulatory pathways (Homo sapiens)
        
        SARS-CoV-2 N binds to 14-3-3 proteins (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)
        
        14-3-3 dimer:N [cytosol] (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)

Programmed Cell Death (Homo sapiens)

- Apoptosis (Homo sapiens)
  - Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Activation of BH3-only proteins (Homo sapiens)
      - Activation of BAD and translocation to mitochondria (Homo sapiens)
        
        Activation of BAD by calcineurin (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)
        
        14-3-3 proteins:p-S99-BAD complex [cytosol] (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)
        
        Sequestration of BAD protein by 14-3-3 (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)
        
        14-3-3 proteins:p-S99-BAD complex [cytosol] (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases activate PKNs (Homo sapiens)
        
        Association of p-S216-CDC25C with 14-3-3 proteins (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)
        
        p-S216-CDC25C:14-3-3 protein complex [cytosol] (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Translocation of SLC2A4 (GLUT4) to the plasma membrane (Homo sapiens)
    - 14-3-3 Binds p-S237-TBC1D1 (Homo sapiens)
      - 14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)
      - p-S237-TBC1D1:14-3-3 [cytosol] (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)
    - 14-3-3 binds p-5S,T642-AS160 (TBC1D4) (Homo sapiens)
      - 14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)
      - p-5S,T642-AS160:14-3-3:IRAP [cytoplasmic vesicle membrane] (Homo sapiens)
        
        Phospho AS160:14-3-3 [cytoplasmic vesicle membrane] (Homo sapiens)
        
        14-3-3 dimer [cytosol] (Homo sapiens)
        
        YWHAH dimer [cytosol] (Homo sapiens)
        
        YWHAH [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q04917 YWHAH

Gene Names

YWHAH, YWHA1

Chain

initiator methionine:1, chain:2-246

Reference Genes

BioGPS Gene:7533 YWHAH

COSMIC (genes):YWHAH YWHAH

CTD Gene:7533 YWHAH

dbSNP Gene:7533 YWHAH

ENSEMBL:ENSG00000128245 YWHAH

ENSEMBL:ENSG00000128245.15 YWHAH

HGNC:12853 YWHAH

KEGG Gene (Homo sapiens):7533 YWHAH

Monarch:7533 YWHAH

NCBI Gene:7533 YWHAH

OMIM:113508 YWHAH

UCSC:Q04917 YWHAH

Reference Transcript

RefSeq:NM_003405.3 YWHAH

Other Identifiers

11715593_s_at

11756255_x_at

1424_s_at

201020_PM_at

201020_at

3943208

3943209

3943218

3943219

3943220

3943221

3943222

7533

8072577

A_14_P109968

A_23_P103070

D78577_s_at

GE60439

GO:0002028

GO:0003779

GO:0003824

GO:0004497

GO:0005159

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006629

GO:0006713

GO:0006886

GO:0007165

GO:0008092

GO:0014704

GO:0016491

GO:0017080

GO:0019899

GO:0019904

GO:0021762

GO:0023052

GO:0030154

GO:0035259

GO:0042802

GO:0042921

GO:0043226

GO:0044325

GO:0045664

GO:0045893

GO:0046982

GO:0048167

GO:0048856

GO:0050774

GO:0055085

GO:0070062

GO:0086010

GO:0098772

GO:0098793

GO:0098978

GO:0099171

GO:0150048

GO:2000649

HMNXSV003032556

ILMN_1728512

PH_hs_0023146

TC22000233.hg

g4507950_3p_at

Participates

as a component of

YWHAH dimer [cytosol] (Homo sapiens)

Inferred To

YWHAH [cytosol] (Bos taurus)

YWHAH [cytosol] (Caenorhabditis elegans)

YWHAH [cytosol] (Canis familiaris)

YWHAH [cytosol] (Gallus gallus)

YWHAH [cytosol] (Sus scrofa)

Homologues of YWHAH [cytosol] (Caenorhabditis elegans)

14-3-3zeta [cytosol] (Drosophila melanogaster)

par-5 [cytosol] (Caenorhabditis elegans)

14-3-3 eta [cytosol] (Mus musculus)

Ywhah [cytosol] (Rattus norvegicus)

ywhah [cytosol] (Xenopus tropicalis)

fttB [cytosol] (Dictyostelium discoideum)

fb93e02 [cytosol] (Danio rerio)

ftt-2 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_003396.1

OpenTargets

ENSG00000128245

HPA

ENSG00000128245-YWHAH

GeneCards

Q04917

Ensembl

ENSG00000128245, ENST00000248975, ENSP00000248975

PRO

Q04917

Pharos - Targets

Q04917

Orphanet

28877

PDB

2C74, 2C63, 7NMZ

Interactors (49)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.909	22
UniProt:P56524 HDAC4	3	polySUMO2,3-K559-HDAC4 [nucleoplasm] (R-HSA-4616029) monoSUMO1-K559-HDAC4 [nucleoplasm] (R-HSA-4616016) HDAC4 [nucleoplasm] (R-HSA-351581)	0.788	5
UniProt:P30305 CDC25B	3	p-S50,T69,S160,S321,S470-CDC25B [cytosol] (R-HSA-8863644) CDC25B [cytosol] (R-HSA-157412) CDC25B [nucleoplasm] (R-HSA-69734)	0.779	6
UniProt:P46937 YAP1	7	p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-5S-YAP1 [cytosol] (R-HSA-2028554) YAP1 [cytosol] (R-HSA-1253345) YAP1 [nucleoplasm] (R-HSA-1253322)	0.745	6
UniProt:Q92934 BAD	4	p-S99-BAD [cytosol] (R-HSA-198335) BAD [cytosol] (R-HSA-50662) BAD [mitochondrial outer membrane] (R-HSA-114242) p-S91-BAD [cytosol] (R-HSA-217297)	0.738	5
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.738	5
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.725	4
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.725	7
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.725	7
UniProt:Q02241 KIF23	3	KIF23 [nucleoplasm] (R-HSA-156709) p-S911,S912-KIF23 [nucleoplasm] (R-HSA-156695) KIF23 [cytosol] (R-HSA-1015863)	0.725	4
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.723	4
UniProt:P49815 TSC2	4	p-S939,S1130,T1462-TSC2 [cytosol] (R-HSA-165164) p-S939,T1462-TSC2 [cytosol] (R-HSA-199484) TSC2 [cytosol] (R-HSA-2980548) p-S1387-TSC2 [cytosol] (R-HSA-3132769)	0.688	4
UniProt:P26045 PTPN3	3	PTPN3 [plasma membrane] (R-HSA-5490317) p-S459 PTPN3 [cytosol] (R-HSA-8868111) PTPN3 [cytosol] (R-HSA-8867650)	0.671	4
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.659	3
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.646	4
UniProt:Q9UQC2 GAB2	5	p-Y643-GAB2 [cytosol] (R-HSA-9677149) p-5Y-GAB2 [cytosol] (R-HSA-8855574) p-Y-GAB2 [cytosol] (R-HSA-912529) p-Y452,Y476,Y584-GAB2 [cytosol] (R-HSA-2685615) GAB2 [cytosol] (R-HSA-508239)	0.643	3
UniProt:Q9Y4H2 IRS2	4	IRS2 [plasma membrane] (R-HSA-2428927) IRS2 [cytosol] (R-HSA-57528) p-Y-IRS2 [cytosol] (R-HSA-74774) p-Y-IRS2 [plasma membrane] (R-HSA-198334)	0.643	3
UniProt:Q96B36 AKT1S1	4	AKT1S1 [nucleoplasm] (R-HSA-5083637) p-T246-AKT1S1 [cytosol] (R-HSA-377124) p-S183,T246-AKT1S1 [cytosol] (R-HSA-200163) AKT1S1 [cytosol] (R-HSA-200155)	0.643	4
UniProt:P00519 ABL1	5	p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) ABL1 [nucleoplasm] (R-HSA-5686579) p-S456-ABL1 [nucleoplasm] (R-HSA-5686576)	0.643	3
UniProt:Q02750 MAP2K1	20	MAP2K1(9-393) [cytosol] (R-HSA-5211353) MAP2K1(2-8) [cytosol] (R-HSA-5211342) MAP2K1 F53S [cytosol] (R-HSA-9652034) MAP2K1 D67N [cytosol] (R-HSA-9652016) MAP2K1 Q56P [cytosol] (R-HSA-9652064) MAP2K1 E203K [cytosol] (R-HSA-9652023) MAP2K1 V60E [cytosol] (R-HSA-9652067) MAP2K1 P124S [cytosol] (R-HSA-9652062) MAP2K1 Y130C [cytosol] (R-HSA-9652101) MAP2K1 C121S [cytosol] (R-HSA-9652013) MAP2K1 G128V [cytosol] (R-HSA-9652047) MAP2K1 F53L [cytosol] (R-HSA-9652031) MAP2K1 K57N [cytosol] (R-HSA-9652050) MAP2K1 K57T [cytosol] (R-HSA-9652052) MAP2K1 F53V [cytosol] (R-HSA-9652038) MAP2K1 D67Y [cytosol] (R-HSA-9652019) MAP2K1 G128D [cytosol] (R-HSA-9652043) MAP2K1 P124L [cytosol] (R-HSA-9652056) MAP2K1 F53Y [cytosol] (R-HSA-9652041) MAP2K1 L42_K57del [cytosol] (R-HSA-9652026)	0.643	4
UniProt:P30307 CDC25C	8	p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol] (R-HSA-8863654) p-S191-CDC25C [nucleoplasm] (R-HSA-6802968) p-S216-CDC25C [cytosol] (R-HSA-75003) p-S216-CDC25C [nucleoplasm] (R-HSA-156496) CDC25C [nucleoplasm] (R-HSA-69741) p-S198-CDC25C [cytosol] (R-HSA-8981697) CDC25C [cytosol] (R-HSA-157879) p-S198-CDC25C [nucleoplasm] (R-HSA-156668)	0.643	3
UniProt:O43524 FOXO3	9	p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010) p-S215 FOXO3 [cytosol] (R-HSA-5687014) FOXO3 [cytosol] (R-HSA-5687032) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289) FOXO3 [nucleoplasm] (R-HSA-199305)	0.643	3
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637)	0.643	3
UniProt:Q96L34 MARK4	1	MARK4 [cytosol] (R-HSA-5626653)	0.641	6
UniProt:P41743 PRKCI	3	PRKCI [nucleoplasm] (R-HSA-9021345) PRKCI [cytosol] (R-HSA-58206) PRKCI [plasma membrane] (R-HSA-420005)	0.623	3
UniProt:Q9HC77 CENPJ	2	CENPJ [cytosol] (R-HSA-380291) p-S589,S595-CENPJ [cytosol] (R-HSA-6801670)	0.615	3
UniProt:P30304 CDC25A	6	PolyUb-CDC25A [cytosol] (R-HSA-6782810) CDC25A [nucleoplasm] (R-HSA-143487) CDC25A [cytosol] (R-HSA-157410) p-S124-CDC25A [nucleoplasm] (R-HSA-143488) p-S124-CDC25A [cytosol] (R-HSA-69588) p-S40,S116,S261-CDC25A [nucleoplasm] (R-HSA-8863634)	0.569	3
UniProt:Q70EL4 USP43	1	USP43 [nucleoplasm] (R-HSA-5653784)	0.564	2
UniProt:O15530 PDPK1	2	PDPK1 [cytosol] (R-HSA-202210) PDPK1 [plasma membrane] (R-HSA-61459)	0.564	3
UniProt:Q9UQ35 SRRM2	1	SRRM2 [nucleoplasm] (R-HSA-8865888)	0.527	2
UniProt:P29074 PTPN4	2	PTPN4 [nucleoplasm] (R-HSA-9008925) PTPN4 [cytosol] (R-HSA-8877173)	0.527	2
UniProt:O60573 EIF4E2	1	EIF4E2 [cytosol] (R-HSA-1678822)	0.527	2
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.527	2
UniProt:Q15643 TRIP11	4	TRIP11 [transport vesicle] (R-HSA-8847847) TRIP11 [Golgi membrane] (R-HSA-5617602) TRIP11(2-1724)-FLT3(594-993) fusion [cytosol] (R-HSA-9703323) TRIP11(2-1724)-p-4Y-FLT3(594-993) fusion [cytosol] (R-HSA-9703304)	0.527	2
UniProt:Q8IX03 WWC1	1	WWC1 [cytosol] (R-HSA-2038400)	0.527	2
UniProt:Q9Y580 RBM7	1	RBM7 [nucleoplasm] (R-HSA-8985564)	0.527	2
UniProt:O75044 SRGAP2	1	SRGAP2 [cytosol] (R-HSA-195131)	0.527	2
UniProt:P36507 MAP2K2	12	MAP2K2(1-10) [cytosol] (R-HSA-5211334) MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2 C125S [cytosol] (R-HSA-9652070) MAP2K2 P128Q [cytosol] (R-HSA-9652082) MAP2K2 V35M [cytosol] (R-HSA-9652086) MAP2K2 Y134C [cytosol] (R-HSA-9652089) p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) MAP2K2 [cytosol] (R-HSA-59504) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2 N126D [cytosol] (R-HSA-9652079) MAP2K2 L46F [cytosol] (R-HSA-9652076) MAP2K2 F57C [cytosol] (R-HSA-9652073)	0.527	3
UniProt:Q96PU5 NEDD4L	2	NEDD4L [cytosol] (R-HSA-976003) NEDD4L [nucleoplasm] (R-HSA-2176420)	0.527	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	3
UniProt:Q86TI0 TBC1D1	2	TBC1D1 [cytoplasmic vesicle membrane] (R-HSA-1454718) p-S237-TBC1D1 [cytosol] (R-HSA-1454673)	0.527	2
UniProt:Q9JIR4	1	RIMS1 [cytosol] (R-RNO-210407)	0.527	3
UniProt:P40818 USP8	2	USP8 [cytosol] (R-HSA-917720) p-T945-USP8 [cytosol] (R-HSA-1358714)	0.527	2
UniProt:Q92574 TSC1	2	TSC1 [plasma membrane] (R-HSA-165169) TSC1 [cytosol] (R-HSA-5672338)	0.527	2
UniProt:P47974 ZFP36L2	1	ZFP36L2 [cytosol] (R-HSA-9819194)	0.527	2
UniProt:Q13009 TIAM1	2	p-Y829-TIAM1 [cytosol] (R-HSA-3928461) TIAM1 [cytosol] (R-HSA-195013)	0.527	2
UniProt:P48552 NRIP1	2	monoSUMO1-K756,K1154-NRIP1 [nucleoplasm] (R-HSA-4086057) NRIP1 [nucleoplasm] (R-HSA-4086031)	0.489	2
UniProt:Q96ST8 CEP89	1	CEP89 [cytosol] (R-HSA-5620930)	0.483	3
UniProt:Q6PJG9 LRFN4	1	SALM3 [plasma membrane] (R-HSA-197883)	0.462	3

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