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LNPEP [cytoplasmic vesicle membrane]
Stable Identifier
R-HSA-1445121
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytoplasmic vesicle membrane
Synonyms
IRAP, LNPEP, Leucyl-cystinyl aminopeptidase, LCAP_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Translocation of SLC2A4 (GLUT4) to the plasma membrane (Homo sapiens)
14-3-3 binds p-5S,T642-AS160 (TBC1D4) (Homo sapiens)
p-5S,T642-AS160:14-3-3:IRAP [cytoplasmic vesicle membrane] (Homo sapiens)
LNPEP [cytoplasmic vesicle membrane] (Homo sapiens)
p-5S,T642-AS160:IRAP [cytoplasmic vesicle membrane] (Homo sapiens)
LNPEP [cytoplasmic vesicle membrane] (Homo sapiens)
RAB8A,10,13,14 hydrolyze GTP (Homo sapiens)
AS160:IRAP [cytoplasmic vesicle membrane] (Homo sapiens)
LNPEP [cytoplasmic vesicle membrane] (Homo sapiens)
p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4) (Homo sapiens)
AS160:IRAP [cytoplasmic vesicle membrane] (Homo sapiens)
LNPEP [cytoplasmic vesicle membrane] (Homo sapiens)
p-5S,T642-AS160:IRAP [cytoplasmic vesicle membrane] (Homo sapiens)
LNPEP [cytoplasmic vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UIQ6 LNPEP
Gene Names
LNPEP, OTASE
Chain
chain:1-1025, chain:155-1025
Reference Genes
BioGPS Gene:4012 LNPEP
COSMIC (genes):LNPEP LNPEP
CTD Gene:4012 LNPEP
dbSNP Gene:4012 LNPEP
ENSEMBL:ENSG00000113441 LNPEP
ENSEMBL_homo_sapiens_GENE:ENSG00000113441.16 LNPEP
HGNC:6656 LNPEP
KEGG Gene (Homo sapiens):4012 LNPEP
Monarch:4012 LNPEP
NCBI Gene:4012 LNPEP
OMIM:151300 LNPEP
UCSC:Q9UIQ6 LNPEP
Reference Transcript
RefSeq:NM_005575.2 LNPEP
RefSeq:NM_175920.3 LNPEP
Other Identifiers
11729353_a_at
16987565
207904_PM_s_at
207904_s_at
225176_PM_at
225176_at
231866_3p_at
231866_PM_at
231866_at
243532_PM_at
243532_at
2821425
2821429
2821430
2821432
2821434
2821436
2821437
2821440
2821441
2821444
2821446
2821447
2821449
2821451
2821452
2821453
2821456
2821459
2821463
2821464
2821466
2821467
2821468
2821469
2821470
2821471
2821472
2821473
2821474
2821475
2821476
2821477
2821478
2821480
2821482
35421_at
4012
44720_at
60491_at
69509_f_at
69511_r_at
73530_at
76557_at
79589_g_at
8107066
82675_f_at
A_14_P108542
A_14_P118676
A_23_P144677
A_23_P156061
A_24_P132019
A_32_P69475
D50810_at
GE55213
GE885073
GO:0000209
GO:0002376
GO:0002480
GO:0003013
GO:0003824
GO:0004177
GO:0005515
GO:0005576
GO:0005737
GO:0005764
GO:0005765
GO:0005768
GO:0005773
GO:0005829
GO:0005886
GO:0006508
GO:0007165
GO:0007267
GO:0007565
GO:0008217
GO:0008233
GO:0008237
GO:0008270
GO:0016020
GO:0016787
GO:0022414
GO:0023052
GO:0030163
GO:0030659
GO:0031410
GO:0031905
GO:0036211
GO:0042277
GO:0043171
GO:0043226
GO:0046872
GO:0048471
GO:0060395
GO:0070006
GO:0120163
GO:0140096
HMNXSV003004680
HMNXSV003052289
Hs.107882.1.A1_3p_s_at
Hs.116278.0.S1_3p_at
Hs.116278.0.S1_3p_x_at
Hs.123337.0.A1_3p_at
ILMN_1758661
ILMN_1814737
ILMN_1875342
PH_hs_0006922
PH_hs_0025695
TC05000472.hg
g5031880_3p_a_at
Participates
as a component of
p-5S,T642-AS160:14-3-3:IRAP [cytoplasmic vesicle membrane] (Homo sapiens)
p-5S,T642-AS160:IRAP [cytoplasmic vesicle membrane] (Homo sapiens)
AS160:IRAP [cytoplasmic vesicle membrane] (Homo sapiens)
Other forms of this molecule
LNPEP [early endosome lumen]
LNPEP [cytosol]
Cross References
RefSeq
NP_787116.2
,
NP_005566.2
Guide to Pharmacology - Targets
1570
OpenTargets
ENSG00000113441
ZINC - Substances
LCAP_HUMAN
ZINC - Biogenic
LCAP_HUMAN
ZINC target
Q9UIQ6
PRO
Q9UIQ6
PDB
4PJ6
,
5C97
,
4P8Q
,
5JHQ
,
4Z7I
,
7ZYF
,
5MJ6
ZINC - Metabolites
LCAP_HUMAN
IntEnz
3.4.11.3
HPA
ENSG00000113441-LNPEP
GeneCards
Q9UIQ6
Ensembl
ENST00000395770
,
ENST00000231368
,
ENSP00000379117
,
ENSG00000113441
,
ENSP00000231368
Pharos - Targets
Q9UIQ6
ZINC - Predictions - Purchasable
LCAP_HUMAN
HMDB Protein
HMDBP02475
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P27824 CANX
2
CANX [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
0.527
2
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