RAB8A,10,13,14 hydrolyze GTP

Stable Identifier
R-HSA-1445143
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytoplasmic vesicle membrane
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RAB8A,10,13,14 hydrolyze GTP
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RAB proteins have intrinsic weak GTPase activity that is enhanced by RAB-GTPase activating proteins (RAB-GAPs, Sano et al. 2007). The GTPase activity of RAB13 is inferred from other RAB proteins. AS160 (TBC1D4) and TBC1D1 are GAPs that activate the GTPase activity of RAB8A/10/13. Insulin signaling activates AKT, which phosphorylates and inactivates AS160 and TBC1D1, allowing GTP-bound (active) RABs to accumulate.

Literature References
PubMed ID Title Journal Year
15971998 AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain

Mîinea, CP, Sano, H, Kane, S, Sano, E, Fukuda, M, Peränen, J, Lane, WS, Lienhard, GE

Biochem J 2005
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
GTPase activity of GGC-RAB8A,10,13,14:GTP [cytoplasmic vesicle membrane]
Physical Entity
GGC-RAB8A,10,13,14:GTP [cytoplasmic vesicle membrane]
Activity
GTPase activity (0003924)
This event is regulated
Positively by
Inferred From
Rab8a/10/13/14 Hydrolyze GTP (Mus musculus)
Authored
May, B  (2011-07-07)
Reviewed
Klip, A  (2012-08-21)
Created
May, B  (2011-07-13)