p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)

Stable Identifier
R-HSA-1445144
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytoplasmic vesicle membrane, cytosol
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p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)
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As inferred from mouse, AKT2 and, to a lesser extent, AKT1 phosphorylate AS160 (TBC1D4) in response to insulin signaling (Howlett et al. 2007, Karlsson et al 2005). AS160, a RAB GTPase activating protein, interacts with IRAP (LNPEP) and is associated with cytoplasmic vesicles containing GLUT4 (SLC2A4).

Literature References
PubMed ID Title Journal Year
17369524 Resistance exercise and insulin regulate AS160 and interaction with 14-3-3 in human skeletal muscle

Howlett, KF, Sakamoto, K, Garnham, A, Cameron-Smith, D, Hargreaves, M

Diabetes 2007
15919790 Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects

Karlsson, HK, Zierath, JR, Kane, S, Krook, A, Lienhard, GE, Wallberg-Henriksson, H

Diabetes 2005
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-AKT1,p-AKT2 [plasma membrane]
Physical Entity
p-AKT1,p-AKT2 [plasma membrane]
Activity
protein serine/threonine kinase activity (0004674)
Inferred From
Akt Phosphorylates As160 (Tbc1d4) (Mus musculus)
Authored
May, B  (2011-07-07)
Reviewed
Klip, A  (2012-08-21)
Created
May, B  (2011-07-13)