As inferred from mouse, AKT2 and, to a lesser extent, AKT1 phosphorylate AS160 (TBC1D4) in response to insulin signaling (Howlett et al. 2007, Karlsson et al 2005). AS160, a RAB GTPase activating protein, interacts with IRAP (LNPEP) and is associated with cytoplasmic vesicles containing GLUT4 (SLC2A4).
Howlett, KF, Sakamoto, K, Garnham, A, Cameron-Smith, D, Hargreaves, M
Karlsson, HK, Zierath, JR, Kane, S, Krook, A, Lienhard, GE, Wallberg-Henriksson, H
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