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MYO1C [cytosol]
Stable Identifier
R-HSA-1449619
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Myosin-Ic, MYO1C_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
IgG:Leishmania surface:FCGR3A translocates from plasma membrane to the parasitophorous vacuole (Homo sapiens)
Myosin [cytosol] (Homo sapiens)
MYO1C [cytosol] (Homo sapiens)
Myosin-Actin filaments [cytosol] (Homo sapiens)
Myosin [cytosol] (Homo sapiens)
MYO1C [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
Role of myosins in phagosome formation (Homo sapiens)
Myosin [cytosol] (Homo sapiens)
MYO1C [cytosol] (Homo sapiens)
Myosin-Actin filaments [cytosol] (Homo sapiens)
Myosin [cytosol] (Homo sapiens)
MYO1C [cytosol] (Homo sapiens)
Sensory Perception (Homo sapiens)
Sensory processing of sound (Homo sapiens)
Sensory processing of sound by inner hair cells of the cochlea (Homo sapiens)
Mechanoelectrical transduction (MET) channel transports cations from the extracellular region into the cytosol of stereocilia of inner hair cell (Homo sapiens)
MET channel:Tip link:USH1C:USH1G:MYO7A:cytoskeleton (IHC) [plasma membrane] (Homo sapiens)
Inner hair cell stereocilium cytoskeleton [cytosol] (Homo sapiens)
Stereocilium shaft [cytosol] (Homo sapiens)
MYO1C [cytosol] (Homo sapiens)
Sensory processing of sound by outer hair cells of the cochlea (Homo sapiens)
Mechanoelectrical transduction (MET) channel transports cations into the cytosol of stereocilia of cochlear outer hair cell (Homo sapiens)
MET channel:Tip link:USH1C:USH1G:MYO7A:cytoskeleton (OHC) [plasma membrane] (Homo sapiens)
Outer hair cell stereocilium cytoskeleton [cytosol] (Homo sapiens)
Stereocilium shaft [cytosol] (Homo sapiens)
MYO1C [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Translocation of SLC2A4 (GLUT4) to the plasma membrane (Homo sapiens)
RALA:GTP binds MYO1C:CALM1 and activates MYO1C (Homo sapiens)
GGC-RALA:GTP:MYO1C:Calmodulin:F-actin [cytoplasmic vesicle membrane] (Homo sapiens)
MYO1C:CALM1 [cytosol] (Homo sapiens)
MYO1C [cytosol] (Homo sapiens)
MYO1C:CALM1 [cytosol] (Homo sapiens)
MYO1C [cytosol] (Homo sapiens)
SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane (Homo sapiens)
GGC-RALA:GTP:MYO1C:Calmodulin:F-actin [cytoplasmic vesicle membrane] (Homo sapiens)
MYO1C:CALM1 [cytosol] (Homo sapiens)
MYO1C [cytosol] (Homo sapiens)
GGC-RALA:GTP:MYO1C:Exocyst [plasma membrane] (Homo sapiens)
GGC-RALA:GTP:MYO1C:Calmodulin:F-actin [cytoplasmic vesicle membrane] (Homo sapiens)
MYO1C:CALM1 [cytosol] (Homo sapiens)
MYO1C [cytosol] (Homo sapiens)
MYO1C [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00159 MYO1C
Gene Names
MYO1C
Chain
chain:1-1063
Reference Genes
BioGPS Gene:4641 MYO1C
COSMIC (genes):MYO1C MYO1C
CTD Gene:4641 MYO1C
dbSNP Gene:4641 MYO1C
ENSEMBL:ENSG00000197879 MYO1C
ENSEMBL_homo_sapiens_GENE:ENSG00000197879.17 MYO1C
HGNC:7597 MYO1C
KEGG Gene (Homo sapiens):4641 MYO1C
Monarch:4641 MYO1C
NCBI Gene:4641 MYO1C
OMIM:606538 MYO1C
UCSC:O00159 MYO1C
Reference Transcript
RefSeq:NM_033375.4 MYO1C
RefSeq:NM_001080779.1 MYO1C
RefSeq:NM_001080950.1 MYO1C
Other Identifiers
11716452_a_at
11716453_s_at
11716454_x_at
11737769_a_at
11748995_a_at
16839352
214656_3p_x_at
214656_PM_x_at
214656_x_at
225080_PM_at
225080_at
32811_3p_at
32811_PM_at
32811_at
3740166
3740202
3740203
3740204
3740205
3740208
3740209
3740210
3740212
3740214
3740215
3740216
3740218
3740220
3740222
3740223
3740224
3740225
3740226
3740227
3740229
3740230
3740232
3740233
3740234
3740235
3740236
3740237
3740238
3740239
3740240
3740241
3740242
3740243
3740244
3740245
3740248
3740249
3740250
3740251
3740252
3740263
4641
64098_at
65556_at
8011027
A_23_P164022
A_23_P416656
GE85652
GO:0000146
GO:0000166
GO:0002376
GO:0003774
GO:0003779
GO:0005102
GO:0005515
GO:0005516
GO:0005524
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005902
GO:0005903
GO:0005938
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006612
GO:0006886
GO:0007010
GO:0007015
GO:0008092
GO:0009925
GO:0015629
GO:0016020
GO:0016328
GO:0016459
GO:0016461
GO:0016604
GO:0023052
GO:0030050
GO:0030335
GO:0030659
GO:0031267
GO:0031410
GO:0031941
GO:0031982
GO:0032420
GO:0032587
GO:0034330
GO:0035066
GO:0036211
GO:0038089
GO:0042995
GO:0043226
GO:0045121
GO:0045335
GO:0045943
GO:0045944
GO:0045945
GO:0048870
GO:0051015
GO:0060171
GO:0070062
GO:0071346
GO:0090314
GO:0098542
GO:0110016
GO:0140657
GO:1900078
GO:1900748
GO:2000810
HMNXSV003046964
Hs.286226.0.A1_3p_s_at
Hs.297939.4.A1_3p_at
ILMN_1812616
ILMN_2250820
ILMN_2329165
PH_hs_0014804
TC17000974.hg
X98507_at
Participates
as a component of
MYO1C:CALM1 [cytosol] (Homo sapiens)
Stereocilium shaft [cytosol] (Homo sapiens)
as a member of
Myosin [cytosol] (Homo sapiens)
Inferred To
MYO1C [cytosol]
(Bos taurus)
MYO1C [cytosol]
(Canis familiaris)
MYO1C [cytosol]
(Danio rerio)
MYO1C [cytosol]
(Dictyostelium discoideum)
MYO1C [cytosol]
(Drosophila melanogaster)
MYO1C [cytosol]
(Gallus gallus)
MYO1C [cytosol]
(Rattus norvegicus)
MYO1C [cytosol]
(Sus scrofa)
MYO1C [cytosol]
(Xenopus tropicalis)
Myo1c [cytosol]
(Mus musculus)
Cross References
RefSeq
NP_001074248.1
,
NP_203693.3
,
NP_001074419.1
OpenTargets
ENSG00000197879
GeneCards
O00159
HPA
ENSG00000197879-MYO1C
Ensembl
ENST00000648651
,
ENST00000361007
,
ENST00000570984
,
ENSP00000459271
,
ENSP00000496799
,
ENSP00000496954
,
ENSP00000354283
,
ENSP00000493973
,
ENST00000648446
,
ENSG00000197879
,
ENST00000575158
,
ENST00000646049
,
ENSP00000459174
PRO
O00159
Pharos - Targets
O00159
Orphanet
22978
PDB
4BYF
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
20
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.462
2
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