Reactome | Corticosteroids bind to CBG in blood

Corticosteroids bind to CBG in blood

Stable Identifier

R-HSA-1449687

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Corticosteroids are transported in blood bound to Transcortin

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Transcortin (corticosteroid-binding globulin, CBG, Serpin A6) (Hammond et al, 1987) is produced in the liver and functions as a plasma transporter of corticosteroids such as progesterone, aldosterone, cortisol and 11-deoxycorticosterone (Dunn et al, 1981). These hormones are biologically active when not bound to CBG therefore CBG may regulate the bioavailability of these hormones.

Literature References

PubMed ID	Title	Journal	Year
7195404	Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma Dunn, JF, Nisula, BC, Rodbard, D	J Clin Endocrinol Metab	1981
3299377	Primary structure of human corticosteroid binding globulin, deduced from hepatic and pulmonary cDNAs, exhibits homology with serine protease inhibitors Bardin, CW, Harley, MJ, Reventos, J, Hammond, GL, Underhill, DA, Musto, NA, Smith, CL, Goping, IS, Gunsalus, GL	Proc Natl Acad Sci U S A	1987