AMPK-alpha2 phosphorylates TBC1D1

Stable Identifier
R-HSA-1454699
Type
Reaction [transition]
Species
Homo sapiens
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In response to muscle contraction and insulin signaling, AMPK-alpha2 phosphorylates TBC1D1 on serine 237 and probably other residues (Frosig et al. 2010, Vichaiwong et al. 2010). As inferred from rat L6 muscle cells TBC1D1 colocalizes with perinuclear vesicles bearing GLUT4 (SLC2A4) and may be involved in an early step that mobilizes them (Chen et al. 2008). Human TBC1D1 appears cytosolic and is believed to be concentrated near vesicle membranes (Park et al. 2011).

Literature References
PubMed ID Title Journal Year
20701589 Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle

Vichaiwong, K, Purohit, S, An, D, Toyoda, T, Jessen, N, Hirshman, MF, Goodyear, LJ

Biochem J 2010
17995453 Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators

Chen, S, Murphy, J, Toth, R, Campbell, DG, Morrice, NA, Mackintosh, C

Biochem J 2008
21454505 Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation

Park, SY, Jin, W, Woo, JR, Shoelson, SE

J. Biol. Chem. 2011
20837646 Exercise-induced TBC1D1 Ser237 phosphorylation and 14-3-3 protein binding capacity in human skeletal muscle

Frøsig, C, Pehmøller, C, Birk, JB, Richter, EA, Wojtaszewski, JF

J Physiol 2010
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Catalyst Activity
Title
protein serine/threonine kinase activity of AMPK-alpha2:AMPK-beta:AMPK-gamma:AMP [cytosol]
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