TBC1D1 [cytoplasmic vesicle membrane]

Stable Identifier
R-HSA-1454718
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
TBC1 domain family member 1, TBCD1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:O95678 KRT75
General

As inferred from rat L6 muscle cells, TBC1D1 is located in the perinuclear cytosol (Chen et al. 2008). TBC1D1 is observed throughout the cytosol and, based on its homology to TBC1D4 and its interaction with membrane-bound RAB proteins, TBC1D1 is expected to be concentrated near vesicle membranes.

Literature References
PubMed ID Title Journal Year
21454505 Crystal structures of human TBC1D1 and TBC1D4 (AS160) RabGTPase-activating protein (RabGAP) domains reveal critical elements for GLUT4 translocation

Park, SY, Jin, W, Woo, JR, Shoelson, SE

J. Biol. Chem. 2011
17995453 Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators

Chen, S, Murphy, J, Toth, R, Campbell, DG, Morrice, NA, Mackintosh, C

Biochem J 2008
External Reference Information
External Reference
Gene Names
TBC1D1, KIAA1108
Chain
chain:1-1168
Other Identifiers
0004780670
11720224_a_at
11720225_a_at
11720226_s_at
11747994_a_at
11747995_x_at
11752285_a_at
1568713_3p_a_at
1568713_a_at
16965942
212350_at
227945_at
2723758
2723759
2723760
2723769
2723770
2723771
2723807
2723808
2723809
2723814
2723816
2723818
2723824
2723827
2723831
2723832
2723833
2723834
2723835
2723837
2723839
2723860
2723869
2723872
2723885
2723886
2723887
2723889
2723897
2723913
2723920
2723921
2723922
2723923
32506_at
44004_at
79917_at
8094574
A_14_P132551
A_14_P201721
A_23_P73023
A_24_P943613
GE62774
GO:0003674
GO:0005096
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005737
GO:0005829
GO:0006810
GO:0006886
GO:0008150
GO:0015031
GO:0017137
GO:0019899
GO:0030234
GO:0032880
GO:0043226
GO:0061024
GO:0090630
Hs.27356.0.A1_3p_at
Hs.278586.1.A1_3p_at
Hs2.203722.1.A1_3p_a_at
Hs2.203722.1.A1_3p_s_at
Hs2.203722.1.A1_3p_x_at
ILMN_1754947
PH_hs_0024215
PH_hs_0032943
TC04000214.hg
Participant Of
This entity regulates
Other forms of this molecule
Interactors (27)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q8NEU8 DP13B      0.576 4
 UniProt:P61981 YWHAG  1 0.564 2
 UniProt:O75031 HSF2B      0.556 3
 UniProt:Q96JM7-2 L3MBTL3      0.556 3
 UniProt:Q9Y250 LZTS1      0.556 3
 UniProt:Q3B820 F161A      0.556 3
 UniProt:Q2TBE0 C19L2      0.556 3
 UniProt:Q15560 TCEA2      0.556 3
 UniProt:Q8N1B4 VPS52  1 0.556 3
 UniProt:Q96C24 SYTL4  2 0.556 3
 UniProt:Q96T60 PNKP  1 0.556 3
 UniProt:P40222 TXLNA  1 0.556 3
 UniProt:Q6P2D0 ZFP1  1 0.556 3
 UniProt:Q96EZ8 MCRS1  1 0.556 3
 UniProt:P02585 TNNC2  1 0.556 3
 UniProt:Q5JST6 EFHC2      0.556 3
 UniProt:Q3SY00 T10IP      0.556 3
 UniProt:O95678 KRT75  1 0.556 3
 UniProt:Q8TBB1 LNX1  1 0.556 3
 UniProt:Q96IK5 GMCL1      0.556 3
 UniProt:P31273 HXC8      0.556 3
 UniProt:Q8N715 CC185      0.556 3
 UniProt:Q9Y247 FA50B      0.556 3
 UniProt:Q13671 RIN1  1 0.556 3
 IntAct:EBI-16882364 CALM1      0.556 3
 UniProt:Q68G74 LHX8      0.556 3
 UniProt:Q04917 YWHAH  1 0.527 2