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TIMP2 [extracellular region]
Stable Identifier
R-HSA-1454879
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Metalloproteinase inhibitor 2, TIMP2_HUMAN
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Degradation of the extracellular matrix (Homo sapiens)
Activation of Matrix Metalloproteinases (Homo sapiens)
Autocatalytic activation of bound proMMP2 (Homo sapiens)
MMP14:TIMP2:MMP2 intermediate form [plasma membrane] (Homo sapiens)
MMP14:TIMP2 [plasma membrane] (Homo sapiens)
TIMP2 [extracellular region] (Homo sapiens)
MMP14:TIMP:MMP2 [plasma membrane] (Homo sapiens)
MMP14:TIMP2 [plasma membrane] (Homo sapiens)
TIMP2 [extracellular region] (Homo sapiens)
Initial activation of proMMP2 by MMP14 (Homo sapiens)
MMP14:TIMP2:MMP2 intermediate form [plasma membrane] (Homo sapiens)
MMP14:TIMP2 [plasma membrane] (Homo sapiens)
TIMP2 [extracellular region] (Homo sapiens)
MMP14:TIMP2:proMMP2 [plasma membrane] (Homo sapiens)
MMP14:TIMP2 [plasma membrane] (Homo sapiens)
TIMP2 [extracellular region] (Homo sapiens)
MMP14 (MT1-MMP) binds TIMP2 (Homo sapiens)
MMP14:TIMP2 [plasma membrane] (Homo sapiens)
TIMP2 [extracellular region] (Homo sapiens)
TIMP2 [extracellular region] (Homo sapiens)
MMP14:TIMP2 binds proMMP2 (Homo sapiens)
MMP14:TIMP2 [plasma membrane] (Homo sapiens)
TIMP2 [extracellular region] (Homo sapiens)
MMP14:TIMP2:proMMP2 [plasma membrane] (Homo sapiens)
MMP14:TIMP2 [plasma membrane] (Homo sapiens)
TIMP2 [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of ficolin-rich granule lumen proteins (Homo sapiens)
Ficolin-rich granule lumen proteins [extracellular region] (Homo sapiens)
TIMP2 [extracellular region] (Homo sapiens)
Exocytosis of specific granule lumen proteins (Homo sapiens)
Specific granule lumen proteins [extracellular region] (Homo sapiens)
TIMP2 [extracellular region] (Homo sapiens)
Exocytosis of tertiary granule lumen proteins (Homo sapiens)
Tertiary granule lumen proteins [extracellular region] (Homo sapiens)
TIMP2 [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGFBR3 (Homo sapiens)
TGFBR3 PTM regulation (Homo sapiens)
TGFBR3_mem cleavage by MMPs (Homo sapiens)
TIMP2 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P16035 TIMP2
Gene Names
TIMP2
Chain
signal peptide:1-26, chain:27-220
Reference Genes
BioGPS Gene:7077 TIMP2
COSMIC (genes):TIMP2 TIMP2
CTD Gene:7077 TIMP2
dbSNP Gene:7077 TIMP2
ENSEMBL:ENSG00000035862 TIMP2
HGNC:11821 TIMP2
KEGG:hsa:7077 TIMP2
Monarch:7077 TIMP2
NCBI Gene:7077 TIMP2
OMIM:188825 TIMP2
UCSC:P16035 TIMP2
Reference Transcript
RefSeq:NM_003255.4 TIMP2
Other Identifiers
11722786_s_at
11748126_a_at
1375_s_at
16849556
16849567
16849574
203167_PM_at
203167_at
224560_PM_at
224560_at
231579_PM_s_at
231579_s_at
34722_at
3772662
3772663
3772664
3772665
3772666
3772667
3772668
3772669
3772672
3772675
3772676
3772677
3772678
3772702
3772703
3772706
3772711
49080_at
7077
8018966
A_23_P107401
A_33_P3382177
GE618711
GE88514
GO:0002020
GO:0005515
GO:0005576
GO:0005615
GO:0008191
GO:0008270
GO:0009725
GO:0030312
GO:0030414
GO:0031012
GO:0034097
GO:0035580
GO:0046872
GO:0051045
GO:0062023
GO:0098772
GO:0140678
GO:1904724
GO:1904813
GO:1905049
HMNXSV003011037
Hs.6441.0.A1_3p_a_at
Hs.6441.0.A1_3p_x_at
ILMN_1664583
ILMN_1721876
ILMN_1749078
M32304_s_at
PH_hs_0030934
TC17002807.hg
g9257247_3p_at
Participates
as a member of
Ficolin-rich granule lumen proteins [extracellular region] (Homo sapiens)
Tertiary granule lumen proteins [extracellular region] (Homo sapiens)
Specific granule lumen proteins [extracellular region] (Homo sapiens)
as a component of
MMP14:TIMP2 [plasma membrane] (Homo sapiens)
as an input of
MMP14 (MT1-MMP) binds TIMP2 (Homo sapiens)
This entity regulates
Negatively
TGFBR3_mem cleavage by MMPs
(Homo sapiens)
Other forms of this molecule
TIMP2 [ficolin-1-rich granule lumen]
TIMP2 [tertiary granule lumen]
TIMP2 [specific granule lumen]
Inferred To
TIMP2 [extracellular region]
(Bos taurus)
TIMP2 [extracellular region]
(Caenorhabditis elegans)
TIMP2 [extracellular region]
(Canis familiaris)
TIMP2 [extracellular region]
(Danio rerio)
TIMP2 [extracellular region]
(Drosophila melanogaster)
TIMP2 [extracellular region]
(Gallus gallus)
TIMP2 [extracellular region]
(Mus musculus)
TIMP2 [extracellular region]
(Rattus norvegicus)
TIMP2 [extracellular region]
(Sus scrofa)
TIMP2 [extracellular region]
(Xenopus tropicalis)
Homologues of TIMP2 [extracellular region]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_003246.1
ENSEMBL
ENSP00000262768
,
ENST00000262768
OpenTargets
ENSG00000035862
HPA
ENSG00000035862-TIMP2
PRO
P16035
Pharos - Targets
P16035
PDB
2TMP
,
1GXD
,
1BR9
,
4ILW
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08253 MMP2
5
MMP2(110-660) [extracellular region]
(R-HSA-381456)
MMP2(30-660) [extracellular region]
(R-HSA-1604364)
MMP2(67-660) [extracellular region]
(R-HSA-1604345)
MMP2(30-66) [extracellular region]
(R-HSA-1604347)
MMP2(67-109) [extracellular region]
(R-HSA-1604371)
0.688
3
UniProt:P50281 MMP14
4
MMP14 [plasma membrane]
(R-HSA-1442472)
MMP14(21-582) [Golgi lumen]
(R-HSA-1604689)
MMP14 [Golgi lumen]
(R-HSA-1604724)
MMP14 [Golgi membrane]
(R-HSA-9858808)
0.564
4
UniProt:Q9UHD9 UBQLN2
1
UBQLN2 [cytosol]
(R-HSA-8866007)
0.556
3
UniProt:O95789 ZMYM6
0.527
2
UniProt:P35625 TIMP3
2
TIMP3 [extracellular region]
(R-HSA-1430774)
TIMP3 [platelet dense granule lumen]
(R-HSA-8848904)
0.527
2
UniProt:P22830 FECH
1
FECH [mitochondrial inner membrane]
(R-HSA-189441)
0.499
2
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