The ABCC family mediates organic anion transport

Stable Identifier
R-HSA-1454916
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The multidrug resistance associated protein (MRPs) subfamily of the ABC transporter family can transport a wide and diverse range of organic anions that can be endogenous compounds and xenobiotics and their metabolites. All human MRPs (except MRP9) can mediate these transport reactions (Deeley et al. 2006). Separately, specific reactions have also been annotated to describe the roles of ABCC4 in platelet dense granule assembly, of ABCC1 in LTC4 export (an aspect of leukotriene synthesis), and of ABCC3 in bile salt efflux.

Literature References
PubMed ID Title Journal Year
16816140 Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins

Deeley, RG, Westlake, C, Cole, SP

Physiol Rev 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ATPase-coupled anion transmembrane transporter activity of ABCCs [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created