ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region

Stable Identifier
R-HSA-1467457
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Some members of the ABC transporter superfamily are able to mediate the efflux of a broad range of cytotoxic drugs from cells, leading to the name multidrug resistance (MDR) proteins (Seeger and van Veen 2009). The ABCB1 (P-glycoprotein 1[PGP], multidrug resistance protein 1 [MRP1]) is the most characterised MDR (Shen et al. 1986, Gottesman & Pastan 1988). ABCB5 (Frank et al. 2005) and ABCA8 (Tsuruoka et al. 2002) are newer members of MDRs.

Literature References
PubMed ID Title Journal Year
12379217 Functional analysis of ABCA8, a new drug transporter

Tsuruoka, S, Ishibashi, K, Yamamoto, H, Wakaumi, M, Suzuki, M, Schwartz, GJ, Imai, M, Fujimura, A

Biochem Biophys Res Commun 2002
15899824 ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma

Frank, NY, Margaryan, A, Huang, Y, Schatton, T, Waaga-Gasser, AM, Gasser, M, Sayegh, MH, Sadee, W, Frank, MH

Cancer Res 2005
3457471 Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification

Shen, DW, Fojo, A, Chin, JE, Roninson, IB, Richert, N, Pastan, I, Gottesman, MM

Science 1986
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
xenobiotic transmembrane transporting ATPase activity of ABCA8/B1/B5 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Created