ABCA4 mediates atRAL transport

Stable Identifier
R-HSA-1467466
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
atRAL(membrane) is transported to atRAL(cytosol) by ABCA4
Locations in the PathwayBrowser
Summation

Rhodopsin (RHO) is localised to both the disc membrane and the plasma membrane of rod outer segments (ROS). All-trans-retinal (atRAL) released from rhodopsin during the bleaching process, needs to translocate to the cytosol for reduction to all-trans-retinol (atROL) via all-trans-retinol dehydrogenases. Although atRAL can diffuse through membranes unaided, there exists an ABC transporter on disc membranes which may facilitate the transport of excess atRAL. Retinal-specific ATP-binding cassette transporter (ABCA4, ABCR) is the only ABC transporter which mediates the transport of retinoids (Biswas & Biswas 2000). Studies using bovine ABCA4 demonstrates atRAL transport (Sun et al. 1999). Human ABCR was found to be identical to the ABC transporter linked to Stargardt's disease type 1 (STGD1, MIM:248200), a cause of macular degeneration in childhood (Nasonkin et al. 1998).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
eye pigment precursor transporter activity of ABCA4 [photoreceptor disc membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed