Beta-defensins are secreted

Stable Identifier
R-HSA-1471322
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi lumen, extracellular region
ReviewStatus
5/5
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Beta-defensins are secreted
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Beta defensin precursors are more simple in structure than those of alpha defensins, having a signal sequence, a short or absent propiece and the mature defensin sequence at the C-terminus. The signal sequence is cleaved off by a signal peptidase in the endoplasmic reticulum (Ganz 2003). Mature beta defensins 1, 2, 3, and 4 are secreted primarily by epithelial cells but are also produced by some immune cells such as monocytes, macrophages and dendritic cells (Duits et al. 2000, Ryan et al. 2003).
Literature References
PubMed ID Title Journal Year
21122132 Tissue-specific human beta-defensins (HBD)1, HBD2, and HBD3 secretion from human extra-placental membranes stimulated with Escherichia coli

Garcia-Lopez, G, Flores-Espinosa, P, Zaga-Clavellina, V

Reprod Biol Endocrinol 2010
9541493 Human beta-defensin-1: an antimicrobial peptide of urogenital tissues

Valore, EV, Park, CH, Quayle, AJ, Wiles, KR, McCray PB, Jr, Ganz, T

J Clin Invest 1998
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Orthologous Events
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Authored
Jupe, S  (2011-04-28)
Reviewed
McDermott, AM  (2011-11-03)
Created
Jupe, S  (2011-08-03)
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