Phosphorylation of p-KIT on Y900 by Src kinases

Stable Identifier
R-HSA-1472121
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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Phosphorylation of p-KIT on Y900 by Src kinases
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Src family of tyrosine kinases phosphorylate KIT on Y900 located in the second part of the tyrosine kinase domain. This phosphorylated tyrosine acts as a docking site for p85alpha regulatory subunit of PI3K and the adapter protein CRKII. CRKII does not interact directly with KIT but is recruited indirectly by binding to p85alpha subunit of PI3K. Thus, in this case the p85 subunit acts as an adapter between KIT and CRKII, and not to recruit PI3-kinase. (Lennartsson et al. 2003).
Literature References
PubMed ID Title Journal Year
12878163 Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk

Hellman, U, Lennartsson, J, Rönnstrand, L, Engström, U, Wernstedt, C

Exp Cell Res 2003
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Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of SFKs:p-KIT complex [plasma membrane]

Physical Entity
SFKs:p-KIT complex [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Phosphorylation of p-KIT on Y900 by Src kinases (Bos taurus)
Phosphorylation of p-KIT on Y900 by Src kinases (Canis familiaris)
Phosphorylation of p-KIT on Y900 by Src kinases (Danio rerio)
Phosphorylation of p-KIT on Y900 by Src kinases (Gallus gallus)
Phosphorylation of p-KIT on Y900 by Src kinases (Mus musculus)
Phosphorylation of p-KIT on Y900 by Src kinases (Rattus norvegicus)
Phosphorylation of p-KIT on Y900 by Src kinases (Sus scrofa)
Phosphorylation of p-KIT on Y900 by Src kinases (Xenopus tropicalis)
Authored
Garapati, P V  (2011-07-11)
Reviewed
Rönnstrand, L  (2011-08-22)
Created
Garapati, P V  (2011-08-03)
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