Phosphorylation of p-KIT on Y900 by Src kinases

Stable Identifier
R-HSA-1472121
Type
Reaction
Species
Homo sapiens
Compartment
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Src family of tyrosine kinases phosphorylate KIT on Y900 located in the second part of the tyrosine kinase domain. This phosphorylated tyrosine acts as a docking site for p85alpha regulatory subunit of PI3K and the adapter protein CRKII. CRKII does not interact directly with KIT but is recruited indirectly by binding to p85alpha subunit of PI3K. Thus, in this case the p85 subunit acts as an adapter between KIT and CRKII, and not to recruit PI3-kinase. (Lennartsson et al. 2003).

Literature References
PubMed ID Title Journal Year
12878163 Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk

Lennartsson, J, Wernstedt, C, Engström, U, Hellman, U, Rönnstrand, L

Exp Cell Res 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of SFKs:p-KIT complex [plasma membrane]
Physical Entity
Activity
Orthologous Events
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